Development of Secondary Acute Myeloid Leukemia in a Pediatric Patient Concurrently Receiving Primary Therapy for Ewing Sarcoma

Brandon R McNew; Benjamin W Darbro; Deqin Ma; David J Gordon

doi:10.1097/MPH.0000000000000924

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Development of Secondary Acute Myeloid Leukemia in a Pediatric Patient Concurrently Receiving Primary Therapy for Ewing Sarcoma

Journal article

Open access

Peer reviewed

Development of Secondary Acute Myeloid Leukemia in a Pediatric Patient Concurrently Receiving Primary Therapy for Ewing Sarcoma

Brandon R McNew, Benjamin W Darbro, Deqin Ma and David J Gordon

Journal of pediatric hematology/oncology, Vol.39(7), pp.e370-e372

10/2017

DOI: 10.1097/MPH.0000000000000924

PMCID: PMC5772896

PMID: 28816792

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https://www.ncbi.nlm.nih.gov/pmc/articles/5772896View

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Abstract

Ewing sarcoma is a pediatric bone and soft tissue sarcoma that requires intensive therapy, which can cause secondary malignancies. We present a rare case of early, treatment-related AML in a pediatric patient concurrently receiving primary therapy for Ewing sarcoma. Despite AML-directed therapy, our patient died secondary to complications of hyperleukocytosis. Cytogenetic and mutation profiling of the leukemia cells revealed the DNA-topoisomerase-II-inhibitor-associated t(9;11)(p22;q23) translocation and clonal KRAS and BRAF mutations. This report highlights the importance of monitoring for treatment-related effects in cancer therapy, as well as the need for novel, less toxic approaches in Ewing sarcoma therapy.

Translocation, Genetic

Humans

Sarcoma, Ewing - pathology

Secondary Prevention

Sarcoma, Ewing - drug therapy

Leukocytosis

Neoplasms, Second Primary

Adolescent

Fatal Outcome

Female

Mutation

Leukemia, Myeloid, Acute - chemically induced

Leukemia, Myeloid, Acute - genetics

Details

Title: Subtitle: Development of Secondary Acute Myeloid Leukemia in a Pediatric Patient Concurrently Receiving Primary Therapy for Ewing Sarcoma
Creators: Brandon R McNew - University of Iowa Hospitals and Clinics, Iowa City, IA †Blank Children's Cancer and Blood Disorder Center, Des Moines, IA
Benjamin W Darbro
Deqin Ma
David J Gordon
Resource Type: Journal article
Publication Details: Journal of pediatric hematology/oncology, Vol.39(7), pp.e370-e372
DOI: 10.1097/MPH.0000000000000924
PMID: 28816792
PMCID: PMC5772896
NLM abbreviation: J Pediatr Hematol Oncol
ISSN: 1077-4114
eISSN: 1536-3678
Publisher: United States
Grant note: P30 CA086862 / NCI NIH HHS
Language: English
Date published: 10/2017
Academic Unit: Stead Family Department of Pediatrics; Pathology; Medical Genetics and Genomics; Hematology/Oncology
Record Identifier: 9984047681802771

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