Journal article
Development of a murine model to study the cerebral pathogenesis of Aspergillus fumigatus
mSphere, Vol.8(6), e0046823
12/20/2023
DOI: 10.1128/msphere.00468-23
PMCID: PMC10732035
PMID: 38010145
Abstract
IMPORTANCE Molds are environmental fungi that can cause disease in immunocompromised individuals. The most common pathogenic mold is Aspergillus fumigatus, which is typically inhaled into the lungs and causes invasive pulmonary disease. In a subset of these patients, this infection can spread from the lungs to other organs including the brain, resulting in cerebral aspergillosis. How A. fumigatus causes brain disease is not well understood and these infections are associated with extremely high mortality rates. Thus, we developed an animal model to study the pathogenesis of cerebral aspergillosis to better understand this disease and develop better treatments for these life-threatening infections.
Details
- Title: Subtitle
- Development of a murine model to study the cerebral pathogenesis of Aspergillus fumigatus
- Creators
- Martin T Kelty - University of IowaSarah R Beattie - University of Iowa
- Resource Type
- Journal article
- Publication Details
- mSphere, Vol.8(6), e0046823
- DOI
- 10.1128/msphere.00468-23
- PMID
- 38010145
- PMCID
- PMC10732035
- NLM abbreviation
- mSphere
- eISSN
- 2379-5042
- Grant note
- name: HHS | National Institutes of Health, award: 1K12TR004382-01
- Language
- English
- Electronic publication date
- 11/27/2023
- Date published
- 12/20/2023
- Academic Unit
- Stead Family Department of Pediatrics; Infectious Disease (Pediatrics)
- Record Identifier
- 9984516957302771
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