Development of a preliminary pediatric tracheal growth model from magnetic resonance images

Richard L Amendola; Joseph M Reinhardt; M Bridget Zimmerman; Yutaka Sato; Henry R Diggelmann; Deborah S F Kacmarynski

doi:10.1002/lary.24547

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Development of a preliminary pediatric tracheal growth model from magnetic resonance images

Journal article

Open access

Peer reviewed

Development of a preliminary pediatric tracheal growth model from magnetic resonance images

Richard L Amendola, Joseph M Reinhardt, M Bridget Zimmerman, Yutaka Sato, Henry R Diggelmann and Deborah S F Kacmarynski

The Laryngoscope, Vol.124(8), pp.1947-1951

08/2014

DOI: 10.1002/lary.24547

PMID: 24307560

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Abstract

To develop a growth model of the minimum cross-sectional area of the normal pediatric trachea with measurements from magnetic resonance images (MRIs) to supplement the clinical criteria used to determine if a child with tracheal stenosis needs surgery. Retrospective imaging review. A total of 81 patients were imaged for a variety of clinical reasons and declared to have normal tracheas fully visible in their T1 magnetic resonance image. Regression analysis was used to identify any contribution that age, gender, and z scores for height and weight have in predicting the minimum cross-sectional area of the trachea. The best-fit model for minimum cross-sectional area is: Area = -0.00451*age(4) + 0.177*age(3) - 2.05*age(2) + 12.6*age + 8.02 (area in mm(2) and age in years). Gender and z scores for height and weight did not provide any additional explanation of variance in tracheal size. Our study demonstrates the potential to create a growth model of the normal trachea based on cross-sectional area of the trachea using MRIs. Even with the relatively small number of patients used to build it, the model has demonstrated some ability to be used as an objective prediction tool when deciding a treatment path for a patient. With continued development of precise, objective measures to diagnose the severity of the tracheal stenosis, more patients can be given early and accurate prognosis and be treated appropriately.

Trachea - growth & development

Tracheal Stenosis - diagnosis

Humans

Child, Preschool

Infant

Male

Magnetic Resonance Imaging

Computer Simulation

Adolescent

Tracheal Stenosis - congenital

Female

Retrospective Studies

Child

Trachea - anatomy & histology

Details

Title: Subtitle: Development of a preliminary pediatric tracheal growth model from magnetic resonance images
Creators: Richard L Amendola - Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, Iowa, U.S.A
Joseph M Reinhardt
M Bridget Zimmerman
Yutaka Sato
Henry R Diggelmann
Deborah S F Kacmarynski
Resource Type: Journal article
Publication Details: The Laryngoscope, Vol.124(8), pp.1947-1951
DOI: 10.1002/lary.24547
PMID: 24307560
NLM abbreviation: Laryngoscope
ISSN: 0023-852X
eISSN: 1531-4995
Publisher: United States
Language: English
Date published: 08/2014
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Stead Family Department of Pediatrics; Biostatistics; Craniofacial Anomalies Research Center; Otolaryngology
Record Identifier: 9983997363802771

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