Journal article
Development of a rapid autopsy program for studies of brain immunity
Journal of neuroimmunology, Vol.163(1), pp.135-144
2005
DOI: 10.1016/j.jneuroim.2005.01.021
PMID: 15885316
Abstract
Human glia are essential cellular models used for studies of neurodegenerative diseases. Fetal neuroglia are commonly used, as they can be recovered in large quantities and sustained for long periods in culture. However, fetal neuroglia may have limitations in reflecting adult diseases and additionally can pose ethical issues in translating products of abortion for research use. To address these concerns, we developed a rapid autopsy program to procure age- and disease-specific neuroglia from adult brain tissues within hours of death. The challenges in developing this initiative, reflecting experiences from 69 autopsies over 4 years, are presented.
Details
- Title: Subtitle
- Development of a rapid autopsy program for studies of brain immunity
- Creators
- Anuja Ghorpade - Laboratories of Cellular Neuroimmunology, Neuropathology and Neuroregeneration, 985215 Nebraska Medical Center, Omaha, NE, 68198-5215, United StatesLeslie Bruch - Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198, United StatesYuri Persidsky - Laboratories of Cellular Neuroimmunology, Neuropathology and Neuroregeneration, 985215 Nebraska Medical Center, Omaha, NE, 68198-5215, United StatesBetty Chin - Laboratories of Cellular Neuroimmunology, Neuropathology and Neuroregeneration, 985215 Nebraska Medical Center, Omaha, NE, 68198-5215, United StatesWilliam H.C Brown - Laboratories of Cellular Neuroimmunology, Neuropathology and Neuroregeneration, 985215 Nebraska Medical Center, Omaha, NE, 68198-5215, United StatesKathleen Borgmann - Laboratories of Cellular Neuroimmunology, Neuropathology and Neuroregeneration, 985215 Nebraska Medical Center, Omaha, NE, 68198-5215, United StatesRaisa Persidsky - Laboratories of Cellular Neuroimmunology, Neuropathology and Neuroregeneration, 985215 Nebraska Medical Center, Omaha, NE, 68198-5215, United StatesLi Wu - Laboratories of Cellular Neuroimmunology, Neuropathology and Neuroregeneration, 985215 Nebraska Medical Center, Omaha, NE, 68198-5215, United StatesSpring Holter - Laboratories of Cellular Neuroimmunology, Neuropathology and Neuroregeneration, 985215 Nebraska Medical Center, Omaha, NE, 68198-5215, United StatesRobin Cotter - Laboratories of Cellular Neuroimmunology, Neuropathology and Neuroregeneration, 985215 Nebraska Medical Center, Omaha, NE, 68198-5215, United StatesJill Faraci - Laboratories of Cellular Neuroimmunology, Neuropathology and Neuroregeneration, 985215 Nebraska Medical Center, Omaha, NE, 68198-5215, United StatesDavid Heilman - Laboratories of Cellular Neuroimmunology, Neuropathology and Neuroregeneration, 985215 Nebraska Medical Center, Omaha, NE, 68198-5215, United StatesVaKara Meyer - Laboratories of Cellular Neuroimmunology, Neuropathology and Neuroregeneration, 985215 Nebraska Medical Center, Omaha, NE, 68198-5215, United StatesJane F Potter - Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198, United StatesSusan Swindells - Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198, United StatesHoward E Gendelman - Laboratories of Cellular Neuroimmunology, Neuropathology and Neuroregeneration, 985215 Nebraska Medical Center, Omaha, NE, 68198-5215, United States
- Resource Type
- Journal article
- Publication Details
- Journal of neuroimmunology, Vol.163(1), pp.135-144
- Publisher
- Elsevier B.V
- DOI
- 10.1016/j.jneuroim.2005.01.021
- PMID
- 15885316
- ISSN
- 0165-5728
- eISSN
- 1872-8421
- Language
- English
- Date published
- 2005
- Academic Unit
- Pathology; Neurosurgery
- Record Identifier
- 9984040306502771
Metrics
8 Record Views