Journal article
Development of an MRI ‐based definition of knee osteoarthritis: Data from the Multicenter Osteoarthritis Study
Arthritis & rheumatology (Hoboken, N.J.), Vol.75(7), pp.1132-1138
07/2023
DOI: 10.1002/art.42454
PMCID: PMC10361157
PMID: 36693143
Abstract
Background
Although the imaging modality of choice for research, there is no widely accepted MRI definition of knee osteoarthritis. We tested the performance of different definitions.
Methods
We studied Multicenter Osteoarthritis Study participants with knee symptoms, posterior-anterior and lateral knee radiographs, and MRIs. Radiographic OA (ROA) was defined as Kellgren-Lawrence grade ≥2 in the tibiofemoral (TF) and/or patellofemoral (PF) joint. Symptomatic OA was defined using a validated questionnaire. MRI findings of cartilage damage, osteophytes, bone marrow lesions (BMLs) and synovitis were scored using the WORMS system.
We compared definitions using combinations of MRI features to the validation criteria of prevalent ROA and symptomatic OA. All combinations included cartilage damage (score ≥2/6) and osteophyte score ≥2/6; adding BMLs and synovitis was also tested. We also evaluated a Delphi panel definition that defined OA differently for the PF and TF joints. For each definition, we calculated sensitivity, specificity, and the area under the curve (AUC).
Results
We included 1185 knees (mean age 61 years, 62% female, 89% white). Of these, 482 had ROA and 524 symptomatic OA. The definitions with cartilage score ≥2/6 and osteophyte score ≥2/6 and ones which added to these BMLs or synovitis ≥1 had the highest sensitivities (95.2%) for prevalent ROA (AUC 0.67), and symptomatic OA. The Delphi panel definition had similar performance but was more complex to apply.
Conclusion
An MRI OA definition requiring cartilage damage and a small osteophyte with or without BMLs or synovitis had the best performance and was simplest for identifying ROA and symptomatic OA.
Details
- Title: Subtitle
- Development of an MRI ‐based definition of knee osteoarthritis: Data from the Multicenter Osteoarthritis Study
- Creators
- Jean W. Liew - Boston UniversityGabriela Rabasa - Boston UniversityMichael LaValley - Boston UniversityJamie Collins - Brigham and Women's HospitalJoshua Stefanik - Northeastern UniversityFrank W. Roemer - Friedrich-Alexander-Universität Erlangen-NürnbergAli Guermazi - VA Boston Healthcare SystemCora E. Lewis - University of Alabama at BirminghamMichael Nevitt - University of California, San FranciscoJames Torner - University of IowaDavid Felson - Boston University
- Resource Type
- Journal article
- Publication Details
- Arthritis & rheumatology (Hoboken, N.J.), Vol.75(7), pp.1132-1138
- DOI
- 10.1002/art.42454
- PMID
- 36693143
- PMCID
- PMC10361157
- NLM abbreviation
- Arthritis Rheumatol
- ISSN
- 2326-5191
- eISSN
- 2326-5205
- Grant note
- DOI: 10.13039/100000069, name: National Institute of Arthritis and Musculoskeletal and Skin Diseases, award: K24‐AR‐070892, P30‐AR‐072571
- Language
- English
- Electronic publication date
- 01/24/2023
- Date published
- 07/2023
- Academic Unit
- Neurology; Epidemiology; Injury Prevention Research Center; Neurosurgery
- Record Identifier
- 9984362759602771
Metrics
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