Journal article
Development of collaterals in the cerebral circulation
Blood vessels, Vol.28(1-3), pp.183-189
1991
DOI: 10.1159/000158860
PMID: 2001469
Abstract
Sudden occlusion of the middle cerebral artery (MCA) in normotensive rats increases blood flow through anastomosing branches into the territory of the occluded artery. Three weeks after MCA occlusion, anastomoses to anterior cerebral branches are increased by more than 50% in luminal diameter. One month after MCA occlusion, blood flow and blood flow reserve to the territory of the occluded MCA are returned to normal levels. In stroke-prone spontaneously hypertensive rats (SHRSP), the anastomoses are significantly narrower and blood flow through the anastomoses is less than in normotensive rats. Tissue infarction invariably develops in the territory of the occluded MCA in SHRSP. We propose that the luminal width of the anastomosis is a major determinant of blood flow into the territory of the occluded artery and of the amount of tissue protected from infarction by collateral circulation.
Details
- Title: Subtitle
- Development of collaterals in the cerebral circulation
- Creators
- P Coyle - Department of Anatomy and Cell Biology, University of Michigan, Ann ArborD D Heistad
- Resource Type
- Journal article
- Publication Details
- Blood vessels, Vol.28(1-3), pp.183-189
- Publisher
- Switzerland
- DOI
- 10.1159/000158860
- PMID
- 2001469
- ISSN
- 0303-6847
- Grant note
- HL31468 / NHLBI NIH HHS HL18575 / NHLBI NIH HHS
- Language
- English
- Date published
- 1991
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040218302771
Metrics
28 Record Views