Development of nevirapine resistance in infants is reduced by use of infant-only single-dose nevirapine plus zidovudine postexposure prophylaxis for the prevention of mother-to-child transmission of HIV-1

Susan H ESHLEMAN; Donald R HOOVER; Sarah E HUDELSON; Shu Chen; Susan A FISCUS; Estelle PIWOWAR-MANNING; J. Brooks JACKSON; Newton I KUMWENDA; Taha E TAHA

doi:10.1086/499967

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Development of nevirapine resistance in infants is reduced by use of infant-only single-dose nevirapine plus zidovudine postexposure prophylaxis for the prevention of mother-to-child transmission of HIV-1

Journal article

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Development of nevirapine resistance in infants is reduced by use of infant-only single-dose nevirapine plus zidovudine postexposure prophylaxis for the prevention of mother-to-child transmission of HIV-1

Susan H ESHLEMAN, Donald R HOOVER, Sarah E HUDELSON, Shu Chen, Susan A FISCUS, Estelle PIWOWAR-MANNING, J. Brooks JACKSON, Newton I KUMWENDA and Taha E TAHA

The Journal of infectious diseases, Vol.193(4), pp.479-481

2006

DOI: 10.1086/499967

PMID: 16425125

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Abstract

We analyzed the development of nevirapine (NVP) resistance in human immunodeficiency virus type 1 (HIV-1)—infected Malawian infants who received regimens containing singledose NVP (SD-NVP) for the prevention of mother-to-child transmission (MTCT) of HIV-1. All infants received SD-NVP, and some randomly received zidovudine (ZDV) as well. Mothers did or did not receive SD-NVP on the basis of when they arrived at the hospital for delivery. In infants 6–8 weeks of age, NVP resistance was less frequent when infants had received SD-NVP plus ZDV and mothers had not received SD-NVP than when infants had received SD-NVP alone and mothers had received SD-NVP (4/15 [27%] vs. 20123 [87%]; P < .001). The risk of MTCT of HIV-1 was comparable with these regimens. Infant-only prophylaxis also eliminates the development of NVP resistance in mothers.

Infectious Diseases

Microbiology

Virology

Fundamental and applied biological sciences. Psychology

Miscellaneous

Biological and medical sciences

Medical sciences

Details

Title: Subtitle: Development of nevirapine resistance in infants is reduced by use of infant-only single-dose nevirapine plus zidovudine postexposure prophylaxis for the prevention of mother-to-child transmission of HIV-1
Creators: Susan H ESHLEMAN - Johns Hopkins University, Baltimore, Maryland, United States
Donald R HOOVER - Rutgers University, Piscataway, New Jersey, United States
Sarah E HUDELSON - Johns Hopkins University, Baltimore, Maryland, United States
Shu Chen - Johns Hopkins University, Baltimore, Maryland, United States
Susan A FISCUS - University of North Carolina, Chapel Hill, United States
Estelle PIWOWAR-MANNING - Johns Hopkins University, Baltimore, Maryland, United States
J. Brooks JACKSON - Johns Hopkins University, Baltimore, Maryland, United States
Newton I KUMWENDA - Johns Hopkins University, Baltimore, Maryland, United States
Taha E TAHA - Johns Hopkins University, Baltimore, Maryland, United States
Resource Type: Journal article
Publication Details: The Journal of infectious diseases, Vol.193(4), pp.479-481
DOI: 10.1086/499967
PMID: 16425125
NLM abbreviation: J Infect Dis
ISSN: 0022-1899
eISSN: 1537-6613
Publisher: University of Chicago Press; Chicago, IL
Language: English
Date published: 2006
Academic Unit: Pathology; VPMA - Administration
Record Identifier: 9984047688102771

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