Journal article
Development of retroviral vectors for gene transfer to airway epithelia
Current opinion in molecular therapeutics, Vol.2(5), pp.497-506
10/2000
PMID: 11249752
Abstract
Retroviral vectors offer several potential advantages for attaining persistent expression of a therapeutic gene in airway epithelia for diseases such as cystic fibrosis. However, several problems have limited their application. Developments in vector production and the advent of lentiviral vectors have increased the investigation of recombinant retrovirus for gene transfer to airway epithelia. In addition, an improved understanding of some of the barriers limiting gene transfer has led to increased transduction efficiencies. The development of novel vector formulations and the use of new envelope pseudotypes are examples of recent findings that are leading to advances in this field.
Details
- Title: Subtitle
- Development of retroviral vectors for gene transfer to airway epithelia
- Creators
- G Wang - Program in Gene Therapy, Department of Pediatrics, University of Iowa College of Medicine, Iowa City, IA 52242, USAP L SinnP B McCray Jr
- Resource Type
- Journal article
- Publication Details
- Current opinion in molecular therapeutics, Vol.2(5), pp.497-506
- PMID
- 11249752
- ISSN
- 1464-8431
- eISSN
- 2040-3445
- Grant note
- HL-51670 / NHLBI NIH HHS HL51670-05 / NHLBI NIH HHS R01 HL-61460 / NHLBI NIH HHS P30 DK54759 / NIDDK NIH HHS
- Language
- English
- Date published
- 10/2000
- Academic Unit
- Microbiology and Immunology; Pulmonary Medicine; Stead Family Department of Pediatrics; Internal Medicine
- Record Identifier
- 9984093331102771
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