Journal article
Development of smokeless tobacco‐induced oral mucosal lesions
Journal of oral pathology & medicine, Vol.27(8), pp.388-394
09/1998
DOI: 10.1111/j.1600-0714.1998.tb01972.x
PMID: 9736428
Abstract
This study examined clinical and inflammatory mediator parameters during the development of snuff‐induced mucosal lesions. Nineteen smokeless tobacco (ST) users placed moist snuff at designated new placement sites over either a 2‐or 7‐day period. By day 2, the predominant clinical alteration was an erythematous reaction, and one‐third of the subjects demonstrated white striations in combination with erythema or ulceration. By 7 days, 56% of the subjects displayed white striated lesions. Tissue concentrations (pg/mg) of IL‐1β were 4.6±1.6 at new placement sites as compared with 0.7±0.4 at control sites (P<0.05). PGE2 and IL‐1α concentrations also were significantly higher (P<0.05) at new placement sites as compared with control sites (9.4±2.2 vs 4.1±0.7 and 6.2±1.3 vs 3.2±0.7, respectively). In view of the recognized role of PGE2 and IL‐1 in immune and inflammatory functions, these mediators may play a role in the pathogenesis of clinical alterations at ST placement sites.
Details
- Title: Subtitle
- Development of smokeless tobacco‐induced oral mucosal lesions
- Creators
- Georgia K JohnsonJeffrey B PayneJames M FiliRichard A ReinhardtConnie C OrganSusan L Slager
- Resource Type
- Journal article
- Publication Details
- Journal of oral pathology & medicine, Vol.27(8), pp.388-394
- Publisher
- Blackwell Publishing Ltd; Oxford, UK
- DOI
- 10.1111/j.1600-0714.1998.tb01972.x
- PMID
- 9736428
- ISSN
- 0904-2512
- eISSN
- 1600-0714
- Number of pages
- 7
- Language
- English
- Date published
- 09/1998
- Academic Unit
- Periodontics
- Record Identifier
- 9984065975902771
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