Journal article
Developmental Aspects of the Renal Responses to Hemorrhage during Converting-Enzyme Inhibition in Fetal Lambs
Circulation research, Vol.54(3), pp.301-312
03/1984
DOI: 10.1161/01.res.54.3.301
PMID: 6321056
Abstract
The role of the renin-angiotensin system in modulating the renal hemodynamic and functional responses to reductions of fetoplacental blood volume (8.8–35.5%) was studied in two groups of fetal lambs (<120 days and >130 days gestation; term 145 days) during infusion of either captopril (experimental fetuses) or dextrose 5% in water (control fetuses). At high hemor rhage levels (level III), renal blood flow decreased and renal vascular resistance increased significantly in both groups of fetuses (<120 days and >130 days), either treated or not treated with captopril. However, at low hemorrhage levels (levels I and II), and contrary to what was observed in young fetuses (<120 days), near-term fetuses (>130 days) receiving captopril showed neither significant decreases in renal blood flow nor increases in renal vascular resistance, whereas untreated fetuses of the same gestational ages demonstrated significant decreases in renal blood flow and increases in renal vascular resistance. It was found in both <120 day and >130 day fetuses that hemorrhage is associated with a decrease in urinary flow rate and free water clearance accompanied by an increase in urine osmolality and sodium reabsorption. It was shown that captopril does not modify this response. The present study also demonstrated that the blood pressure response to hemorrhage was characterized by a similar decrease in <120 day fetuses, whether treated or untreated with captopril. On the other hand, blood pressure did not change in control fetuses >130 days, but decreased slightly in captopril-treated fetuses during hemorrhage. Taken together, the present results tend to suggest that the renin-angiotensin system may be an important modulator of the renal hemodynamic response to low level hemorrhage as fetuses approach term, and may be more important in controlling blood pressure in near-term than in young fetuses.
Details
- Title: Subtitle
- Developmental Aspects of the Renal Responses to Hemorrhage during Converting-Enzyme Inhibition in Fetal Lambs
- Creators
- R Gomez - Department of Pediatrics, and the Cardiovascular Research Center, University of Iowa, Iowa City, IowaJean Robillard
- Resource Type
- Journal article
- Publication Details
- Circulation research, Vol.54(3), pp.301-312
- Publisher
- American Heart Association, Inc
- DOI
- 10.1161/01.res.54.3.301
- PMID
- 6321056
- ISSN
- 0009-7330
- eISSN
- 1524-4571
- Number of pages
- 12
- Language
- English
- Date published
- 03/1984
- Academic Unit
- Molecular Physiology and Biophysics; Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Medicine Administration
- Record Identifier
- 9984773401902771
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