Journal article
Developmental Brain Anomalies in Children With Attention-Deficit Hyperactivity Disorder
Journal of child neurology, Vol.15(2), pp.102-108
02/2000
DOI: 10.1177/088307380001500208
PMID: 10695895
Abstract
The pathoetiology of attention-deficit hyperactivity disorder (ADHD) has been considered to be neurodevelopmental, yet the timing and processes involved are not clearly identified. Neurodevelopmental brain anomalies have been associated with a variety of psychiatric conditions. However, they have never been evaluated in a population of patients with ADHD. This study was designed to determine the frequency of specific developmental brain anomalies in a group of children with ADHD (n = 85; mean age, 10.9 years) and healthy control children (n = 95; mean age, 11.7 years) by visually inspecting brain magnetic resonance imaging scans. Compared to controls, the ADHD group showed an increase in frequency of two developmental anomalies: (1) gray-matter heterotopia, a neuronal migration anomaly, in 2 of 85 patients versus 0 of 95 controls; and (2) posterior fossa abnormality (excess cerebrospinal fluid in the posterior fossa) in 8 of 85 patients versus 2 of 95 controls. There were no differences in frequency of enlarged cavum septi pellucidi between the two groups. These findings support and extend the idea that ADHD is of developmental origin, and further suggest that the timing of aberrant brain development could be in early gestation. (J Child Neurol 2000;15:102-108).
Details
- Title: Subtitle
- Developmental Brain Anomalies in Children With Attention-Deficit Hyperactivity Disorder
- Creators
- Peg Nopoulos - Mental Health Clinical Research Center, University of Iowa Hospitals and Clinics Iowa City, IAStephanie Berg - Mental Health Clinical Research Center, University of Iowa Hospitals and Clinics Iowa City, IAF. Xavier Castellenos - Child Psychiatry Branch, National Institutes of Mental Health Bethesda, MDAymin Delgado - Child Psychiatry Branch, National Institutes of Mental Health Bethesda, MDNancy C Andreasen - Mental Health Clinical Research Center, University of Iowa Hospitals and Clinics Iowa City, IAJudith L Rapoport - Child Psychiatry Branch, National Institutes of Mental Health Bethesda, MD
- Resource Type
- Journal article
- Publication Details
- Journal of child neurology, Vol.15(2), pp.102-108
- Publisher
- Sage Publications; Thousand Oaks, CA
- DOI
- 10.1177/088307380001500208
- PMID
- 10695895
- ISSN
- 0883-0738
- eISSN
- 1708-8283
- Language
- English
- Date published
- 02/2000
- Academic Unit
- Neurology; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute
- Record Identifier
- 9984003450002771
Metrics
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