Journal article
Developmental Changes in Eye-Blink Conditioning and Neuronal Activity in the Cerebellar Interpositus Nucleus
The Journal of neuroscience, Vol.20(2), pp.813-819
01/15/2000
DOI: 10.1523/JNEUROSCI.20-02-00813.2000
PMCID: PMC6772425
PMID: 10632611
Abstract
Neuronal activity was recorded in the cerebellar interpositus nucleus in infant rats during classical conditioning of the eye-blink response. The percentage and amplitude of eye-blink conditioned responses increased as a function of postnatal age. Learning-specific neuronal activity in the cerebellum emerged ontogenetically in parallel with the eye-blink conditioned response. There were also age-specific changes in neuronal activity after the onset of the conditioned and unconditioned stimuli. The results indicate that the development of the eye-blink conditioned response may depend on the development of stimulus-evoked neuronal responses and learning-specific plasticity in the cerebellum. Functional immaturity in the afferent neural pathways may limit the induction of neural plasticity in the cerebellum and thereby limit the development of the eye-blink conditioned response.
Details
- Title: Subtitle
- Developmental Changes in Eye-Blink Conditioning and Neuronal Activity in the Cerebellar Interpositus Nucleus
- Creators
- John H FreemanDaniel A Nicholson
- Resource Type
- Journal article
- Publication Details
- The Journal of neuroscience, Vol.20(2), pp.813-819
- DOI
- 10.1523/JNEUROSCI.20-02-00813.2000
- PMID
- 10632611
- PMCID
- PMC6772425
- ISSN
- 0270-6474
- eISSN
- 1529-2401
- Language
- English
- Date published
- 01/15/2000
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984065858702771
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