Journal article
Developmental Changes in Eye-Blink Conditioning and Neuronal Activity in the Inferior Olive
The Journal of neuroscience, Vol.20(21), pp.8218-8226
11/01/2000
DOI: 10.1523/JNEUROSCI.20-21-08218.2000
PMCID: PMC6772727
PMID: 11050145
Abstract
Neuronal activity was recorded in the dorsal accessory inferior olive in infant rats during classical conditioning of the eye-blink response. The percentage and amplitude of eye-blink conditioned responses (CRs) increased as a function of age. The magnitude of the neuronal response to the unconditioned stimulus (US) decreased with age. There were also age-specific modifications of US-elicited inferior olive neuronal activity during paired trials in which a conditioned eye-blink response was performed. The results indicate that the development of the conditioned eye-blink response may depend on dynamic interactions between multiple developmental processes within the eye-blink circuitry. Differences in the functional maturity of olivo-cerebellar pathways may limit the induction of plasticity in the cerebellum and thereby limit the development of eye-blink conditioned responses.
Details
- Title: Subtitle
- Developmental Changes in Eye-Blink Conditioning and Neuronal Activity in the Inferior Olive
- Creators
- Daniel A NicholsonJohn H Freeman
- Resource Type
- Journal article
- Publication Details
- The Journal of neuroscience, Vol.20(21), pp.8218-8226
- Publisher
- Society for Neuroscience
- DOI
- 10.1523/JNEUROSCI.20-21-08218.2000
- PMID
- 11050145
- PMCID
- PMC6772727
- ISSN
- 0270-6474
- eISSN
- 1529-2401
- Language
- English
- Date published
- 11/01/2000
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984065861202771
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