Developmental Changes in Hippocampal CA1 Single Neuron Firing and Theta Activity during Associative Learning

Jangjin Kim; Mary E Goldsberry; Thomas C Harmon; John H Freeman

doi:10.1371/journal.pone.0164781

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Developmental Changes in Hippocampal CA1 Single Neuron Firing and Theta Activity during Associative Learning

Journal article

Open access

Peer reviewed

Developmental Changes in Hippocampal CA1 Single Neuron Firing and Theta Activity during Associative Learning

Jangjin Kim, Mary E Goldsberry, Thomas C Harmon and John H Freeman

PloS one, Vol.11(10), pp.e0164781-e0164781

2016

DOI: 10.1371/journal.pone.0164781

PMCID: PMC5072650

PMID: 27764172

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Abstract

Hippocampal development is thought to play a crucial role in the emergence of many forms of learning and memory, but ontogenetic changes in hippocampal activity during learning have not been examined thoroughly. We examined the ontogeny of hippocampal function by recording theta and single neuron activity from the dorsal hippocampal CA1 area while rat pups were trained in associative learning. Three different age groups [postnatal days (P)17-19, P21-23, and P24-26] were trained over six sessions using a tone conditioned stimulus (CS) and a periorbital stimulation unconditioned stimulus (US). Learning increased as a function of age, with the P21-23 and P24-26 groups learning faster than the P17-19 group. Age- and learning-related changes in both theta and single neuron activity were observed. CA1 pyramidal cells in the older age groups showed greater task-related activity than the P17-19 group during CS-US paired sessions. The proportion of trials with a significant theta (4-10 Hz) power change, the theta/delta ratio, and theta peak frequency also increased in an age-dependent manner. Finally, spike/theta phase-locking during the CS showed an age-related increase. The findings indicate substantial developmental changes in dorsal hippocampal function that may play a role in the ontogeny of learning and memory.

Electric Stimulation

Synaptic Transmission - physiology

Rats, Long-Evans

Rats

Male

CA1 Region, Hippocampal - growth & development

Conditioning, Eyelid - physiology

Electrodes

CA1 Region, Hippocampal - pathology

Animals

Time Factors

Pyramidal Cells - physiology

Pyramidal Cells - pathology

CA1 Region, Hippocampal - metabolism

Female

Electromyography

Theta Rhythm - physiology

Details

Title: Subtitle: Developmental Changes in Hippocampal CA1 Single Neuron Firing and Theta Activity during Associative Learning
Creators: Jangjin Kim - Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA 52242, United States of America
Mary E Goldsberry - Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA 52242, United States of America
Thomas C Harmon - Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA 52242, United States of America
John H Freeman - Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA 52242, United States of America
Resource Type: Journal article
Publication Details: PloS one, Vol.11(10), pp.e0164781-e0164781
DOI: 10.1371/journal.pone.0164781
PMID: 27764172
PMCID: PMC5072650
NLM abbreviation: PLoS One
ISSN: 1932-6203
eISSN: 1932-6203
Publisher: Public Library of Science; United States
Grant note: R01 NS038890 / NINDS NIH HHS
Language: English
Date published: 2016
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984065859602771

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