Developmental Markers of Genetic Liability to Autism in Parents: A Longitudinal, Multigenerational Study

Molly Losh; Gary E. Martin; Michelle Lee; Jessica Klusek; John Sideris; Sheila Barron; Thomas Wassink

doi:10.1007/s10803-016-2996-x

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Developmental Markers of Genetic Liability to Autism in Parents: A Longitudinal, Multigenerational Study

Journal article

Open access

Peer reviewed

Developmental Markers of Genetic Liability to Autism in Parents: A Longitudinal, Multigenerational Study

Molly Losh, Gary E. Martin, Michelle Lee, Jessica Klusek, John Sideris, Sheila Barron and Thomas Wassink

Journal of autism and developmental disorders, Vol.47(3), pp.834-845

03/01/2017

DOI: 10.1007/s10803-016-2996-x

PMCID: PMC5352796

PMID: 28070788

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Abstract

Genetic liability to autism spectrum disorder (ASD) can be expressed in unaffected relatives through subclinical, genetically meaningful traits, or endophenotypes. This study aimed to identify developmental endophenotypes in parents of individuals with ASD by examining parents' childhood academic development over the school-age period. A cohort of 139 parents of individuals with ASD were studied, along with their children with ASD and 28 controls. Parents' childhood records in the domains of language, reading, and math were studied from grades K-12. Results indicated that relatively lower performance and slower development of skills (particularly language related skills), and an uneven rate of development across domains predicted ASD endophenotypes in adulthood for parents, and the severity of clinical symptoms in children with ASD. These findings may mark childhood indicators of genetic liability to ASD in parents, that could inform understanding of the subclinical expression of ASD genetic liability.

Psychology

Social Sciences

Psychology, Developmental

Details

Title: Subtitle: Developmental Markers of Genetic Liability to Autism in Parents: A Longitudinal, Multigenerational Study
Creators: Molly Losh - Northwestern University
Gary E. Martin - Department of Communication Sciences and Disorders, St. John's University, Staten Island, NY, 10301, USA.
Michelle Lee - Northwestern University
Jessica Klusek - University of South Carolina
John Sideris - University of North Carolina at Chapel Hill
Sheila Barron - University of Iowa
Thomas Wassink - Roy J. and Lucille A. Carver College of Medicine
Resource Type: Journal article
Publication Details: Journal of autism and developmental disorders, Vol.47(3), pp.834-845
DOI: 10.1007/s10803-016-2996-x
PMID: 28070788
PMCID: PMC5352796
NLM abbreviation: J Autism Dev Disord
ISSN: 0162-3257
eISSN: 1573-3432
Publisher: Springer Nature
Number of pages: 12
Grant note: R01DC010191 / NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Deafness & Other Communication Disorders (NIDCD) BCS-0820394 / National Science Foundation; National Science Foundation (NSF) R01MH091131 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) R01DC010191-01A1; R01MH091131 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA 1337 / Autism Speaks
Language: English
Date published: 03/01/2017
Academic Unit: Psychiatry; Stead Family Department of Pediatrics; Psychological and Quantitative Foundations
Record Identifier: 9984281651702771

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