Journal article
Developmental alterations in thermal nociceptive threshold and the distribution of immunoreactive calcitonin gene-related peptide and substance P after neonatal administration of capsaicin in the rat
Neuroscience letters, Vol.97(1), pp.57-62
1989
DOI: 10.1016/0304-3940(89)90139-0
PMID: 2465514
Abstract
Age-dependent changes in thermal nociceptive threshold, as determined by the hot plate test, occurred in rats treated neonatally with capsaicin. From 4 weeks of age, hot plate latency increased to a maximum at 8 weeks of age and then declined to control values by 16 weeks of age. Although substantially diminished by 10 days of age, calcitonin gene-related peptide (CGRP)-like immunoreactivity increased in laminae I and II between 8 and 16 weeks of age. In addition, a dense plexus of CGRP-like immunoreactive fibers appeared in laminae III and IV. Similar changes in substance P-like immunoreactivity were not observed. The parallel timecourse of these alterations suggests that CGRP is involved in nociceptive processing in the spinal cord.
Details
- Title: Subtitle
- Developmental alterations in thermal nociceptive threshold and the distribution of immunoreactive calcitonin gene-related peptide and substance P after neonatal administration of capsaicin in the rat
- Creators
- Donna L Hammond - Department of Central Nervous System Diseases Research, G.D. Searle & Co., Skokie, IL 60077 U.S.AM.A Ruda - Neurobiology and Anesthesiology Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD, 20892 U.S.A
- Resource Type
- Journal article
- Publication Details
- Neuroscience letters, Vol.97(1), pp.57-62
- Publisher
- Elsevier Ireland Ltd
- DOI
- 10.1016/0304-3940(89)90139-0
- PMID
- 2465514
- ISSN
- 0304-3940
- eISSN
- 1872-7972
- Language
- English
- Date published
- 1989
- Academic Unit
- Iowa Neuroscience Institute; Nursing; Anesthesia; Neuroscience and Pharmacology
- Record Identifier
- 9984006490102771
Metrics
12 Record Views