Journal article
Developmental 'awakening' of primary motor cortex to the sensory consequences of movement
eLife, Vol.7, e41841
12/21/2018
DOI: 10.7554/eLife.41841
PMCID: PMC6320070
PMID: 30574868
Abstract
Before primary motor cortex (M1) develops its motor functions, it functions like a somatosensory area. Here, by recording from neurons in the forelimb representation of M1 in postnatal day (P) 8–12 rats, we demonstrate a rapid shift in its sensory responses. At P8-10, M1 neurons respond overwhelmingly to feedback from sleep-related twitches of the forelimb, but the same neurons do not respond to wake-related movements. By P12, M1 neurons suddenly respond to wake movements, a transition that results from opening the sensory gate in the external cuneate nucleus. Also at P12, fewer M1 neurons respond to individual twitches, but the full complement of twitch-related feedback observed at P8 is unmasked through local disinhibition. Finally, through P12, M1 sensory responses originate in the deep thalamorecipient layers, not primary somatosensory cortex. These findings demonstrate that M1 initially establishes a sensory framework upon which its later-emerging role in motor control is built.
Details
- Title: Subtitle
- Developmental 'awakening' of primary motor cortex to the sensory consequences of movement
- Creators
- James C Dooley - Department of Psychological & Brain Sciences, University of Iowa, Iowa, United States, DeLTA Center, University of Iowa, Iowa, United StatesMark S Blumberg - Department of Psychological & Brain Sciences, University of Iowa, Iowa, United States, DeLTA Center, University of Iowa, Iowa, United States, Interdisciplinary Graduate Program in Neuroscience, University of Iowa, Iowa, United States, Department of Biology, University of Iowa, Iowa, United States, Iowa Neuroscience Institute, University of Iowa, Iowa, United States
- Resource Type
- Journal article
- Publication Details
- eLife, Vol.7, e41841
- DOI
- 10.7554/eLife.41841
- PMID
- 30574868
- PMCID
- PMC6320070
- NLM abbreviation
- Elife
- ISSN
- 2050-084X
- eISSN
- 2050-084X
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: R37-HD081168; DOI: 10.13039/100000002, name: National Institutes of Health, award: F32-NS101858
- Language
- English
- Date published
- 12/21/2018
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute; Biology
- Record Identifier
- 9984070014902771
Metrics
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