Journal article
Di-macrocyclic terephthalamide ligands as chelators for the PET radionuclide zirconium-89
Chemical communications (Cambridge, England), Vol.51(12), pp.2301-2303
02/11/2015
DOI: 10.1039/c4cc09256b
PMCID: PMC4507282
PMID: 25556851
Abstract
The development of bifunctional chelators (BFCs) which can stably chelate zirconium-89 ((89)Zr) while being conjugated to targeting molecules is an area of active research. Herein we report the first octadentate terephthalamide ligands, which are easily radiolabeled with (89)Zr and are highly stable in vitro. They represent a novel class of chelators, which are worthy of further development as BFCs for (89)Zr.
Details
- Title: Subtitle
- Di-macrocyclic terephthalamide ligands as chelators for the PET radionuclide zirconium-89
- Creators
- Darpan N Pandya - Wake Forest UniversitySylvie Pailloux - LumiphoreDavid Tatum - University of California, BerkeleyDarren Magda - LumiphoreThaddeus J Wadas - Wake Forest University
- Resource Type
- Journal article
- Publication Details
- Chemical communications (Cambridge, England), Vol.51(12), pp.2301-2303
- DOI
- 10.1039/c4cc09256b
- PMID
- 25556851
- PMCID
- PMC4507282
- NLM abbreviation
- Chem Commun (Camb)
- ISSN
- 1359-7345
- eISSN
- 1364-548X
- Grant note
- R43 GM090395 / NIGMS NIH HHS P30 CA012197 / NCI NIH HHS UL1 TR001420 / NCATS NIH HHS
- Language
- English
- Date published
- 02/11/2015
- Academic Unit
- Radiology; Radiation Oncology
- Record Identifier
- 9984313072502771
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