Diabetes Mellitus in Children with Acute Recurrent and Chronic Pancreatitis: Data From the INternational Study Group of Pediatric Pancreatitis: In Search for a CuRE Cohort

Melena D Bellin; Mark Lowe; M Bridget Zimmerman; Michael Wilschanski; Steven Werlin; David M Troendle; Uzma Shah; Sarah J Schwarzenberg; John F Pohl; Emily Perito; Chee Yee Ooi; Jaimie D Nathan; Veronique D Morinville; Brian A McFerron; Maria R Mascarenhas; Asim Maqbool; Quin Liu; Tom K Lin; Sohail Z Husain; Ryan Himes; Melvin B Heyman; Tanja Gonska; Matthew J Giefer; Cheryl E Gariepy; Steven D Freedman; Douglas S Fishman; Bradley Barth; Maisam Abu-El-Haija; Aliye Uc

doi:10.1097/MPG.0000000000002482

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Diabetes Mellitus in Children with Acute Recurrent and Chronic Pancreatitis: Data From the INternational Study Group of Pediatric Pancreatitis: In Search for a CuRE Cohort

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Diabetes Mellitus in Children with Acute Recurrent and Chronic Pancreatitis: Data From the INternational Study Group of Pediatric Pancreatitis: In Search for a CuRE Cohort

Melena D Bellin, Mark Lowe, M Bridget Zimmerman, Michael Wilschanski, Steven Werlin, David M Troendle, Uzma Shah, Sarah J Schwarzenberg, John F Pohl, Emily Perito, …

Journal of pediatric gastroenterology and nutrition, Vol.69(5), pp.599-606

08/27/2019

DOI: 10.1097/MPG.0000000000002482

PMID: 31460885

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Abstract

Adults with chronic pancreatitis (CP) have a high risk for developing pancreatogenic diabetes mellitus (DM), but little is known regarding potential risk factors for DM in children with acute recurrent pancreatitis (ARP) or CP. We compared demographic and clinical features of children with ARP or CP, with and without DM, in the INternational Study Group of Pediatric Pancreatitis: In Search of a CuRE (INSPPIRE) registry. We reviewed the INSPPIRE database for the presence or absence of physician-diagnosed DM in 397 children, excluding those with total pancreatectomy with islet autotransplantation, enrolled from August 2012 to August 2017. Patient demographics, body mass index percentile, age at disease onset, disease risk factors, disease burden, and treatments were compared between children with DM (n = 24) and without DM (n = 373). 24 children (6.0% of the cohort) had a diagnosis of DM. Five of 13 tested were positive for beta cell autoantibodies. The DM group was 4.2 years (95% CI 3.0, 5.4) older at first episode of acute pancreatitis, and tended to more often have hypertriglyceridemia (odds ratio (OR) 5.21 (1.33, 17.05)), coexisting autoimmune disease (OR 3.94 (0.88, 13.65)) or pancreatic atrophy (OR 3.64 (1.13, 11.59)). Pancreatic atrophy may be more common among children with DM, suggesting more advanced exocrine disease. However, data in this exploratory cohort also suggest increased autoimmunity and hypertriglyceridemia in children with DM, suggesting that risk factors for Type 1 and Type 2 DM respectively may play a role in mediating DM development in children with pancreatitis.

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Title: Subtitle: Diabetes Mellitus in Children with Acute Recurrent and Chronic Pancreatitis: Data From the INternational Study Group of Pediatric Pancreatitis: In Search for a CuRE Cohort
Creators: Melena D Bellin - University of Minnesota
Mark Lowe - Washington University in St. Louis
M Bridget Zimmerman - University of Iowa, Biostatistics
Michael Wilschanski - Hadassah Medical Center
Steven Werlin - Medical College of Wisconsin
David M Troendle - The University of Texas Southwestern Medical Center
Uzma Shah - Harvard University
Sarah J Schwarzenberg - University of Minnesota
John F Pohl - University of Utah
Emily Perito - University of California, San Francisco
Chee Yee Ooi - UNSW Sydney
Jaimie D Nathan - Cincinnati Children's Hospital Medical Center
Veronique D Morinville - Montreal Children, Montreal, QC, Canada
Brian A McFerron - Riley Hospital for Children
Maria R Mascarenhas - University of Pennsylvania
Asim Maqbool - University of Pennsylvania
Quin Liu - Cedars-Sinai Medical Center
Tom K Lin - Cincinnati Children's Hospital Medical Center
Sohail Z Husain - University of Pittsburgh
Ryan Himes - Baylor College of Medicine
Melvin B Heyman - University of California, San Francisco
Tanja Gonska - University of Toronto
Matthew J Giefer - Seattle Childrens Hospital, Seattle, WA, United States
Cheryl E Gariepy - Nationwide Children's Hospital
Steven D Freedman - Harvard University
Douglas S Fishman - Baylor College of Medicine
Bradley Barth - The University of Texas Southwestern Medical Center
Maisam Abu-El-Haija - Cincinnati Children's Hospital Medical Center
Aliye Uc - University of Iowa, Stead Family Department of Pediatrics
Resource Type: Journal article
Publication Details: Journal of pediatric gastroenterology and nutrition, Vol.69(5), pp.599-606
DOI: 10.1097/MPG.0000000000002482
PMID: 31460885
ISSN: 0277-2116
eISSN: 1536-4801
Grant note: DOI: 10.13039/100000001, name: National Science Foundation
Language: English
Date published: 08/27/2019
Academic Unit: Stead Family Department of Pediatrics; Biostatistics; Radiation Oncology; Gastroenterology, Hepatology, Pancreatology, and Nutrition
Record Identifier: 9984227040502771

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