Journal article
Diabetes Mellitus in Living Pancreas Donors: Use of Integrated National Registry and Pharmacy Claims Data to Characterize Donation-Related Health Outcomes
Transplantation, Vol.101(6), pp.1276-1281
06/01/2017
DOI: 10.1097/TP.0000000000001375
PMCID: PMC5288378
PMID: 27482962
Abstract
Background. Living donor pancreas transplant is a potential treatment for diabetic patients with end-organ complications. Although early surgical risks of donation have been reported, long-term medical outcomes in living pancreas donors are not known. Methods. We integrated national Scientific Registry of Transplant Recipients data (1987-2015) with records from a nationwide pharmacy claims warehouse (2005-2015) to examine prescriptions for diabetes medications and supplies as a measure of postdonation diabetes mellitus. To compare outcomes in controls with baseline good health, we matched living pancreas donors to living kidney donors (1:3) by demographic traits and year of donation. Results. Among 73 pancreas donors in the study period, 45 were identified in the pharmacy database:62% women, 84% white, and 80% relatives of the recipient. Over a mean postdonation follow-up period of 16.3 years, 26.7% of pancreas donors filled prescriptions for diabetes treatments, compared with 5.9% of kidney donors (odds ratio, 4.13; 95% confidence interval, 1.91-8.93; P = 0.0003). Use of insulin (11.1% vs 0%) and oral agents (20.0% vs 5.9%; odds ratio, 4.50, 95% confidence interval, 2.09-9.68; P = 0.0001) was also higher in pancreas donors. Conclusions. Diabetes is more common after living pancreas donation than after living kidney donation, supporting clinical consequences from reduced endocrine reserve.
Details
- Title: Subtitle
- Diabetes Mellitus in Living Pancreas Donors: Use of Integrated National Registry and Pharmacy Claims Data to Characterize Donation-Related Health Outcomes
- Creators
- Ngan N. Lam - University of AlbertaMark A. Schnitzler - Saint Louis UniversityDorry L. Segev - Johns Hopkins UniversityGregory P. Hess - University of PennsylvaniaBertram L. Kasiske - Hennepin County Medical CenterHenry B. Randall - Saint Louis UniversityDavid Axelrod - East Carolina UniversityHuiling Xiao - Saint Louis UniversityAmit X. Garg - Western UniversityDaniel C. Brennan - Washington University in St. LouisKrista L. Lentine - Saint Louis University
- Resource Type
- Journal article
- Publication Details
- Transplantation, Vol.101(6), pp.1276-1281
- Publisher
- Lippincott Williams & Wilkins
- DOI
- 10.1097/TP.0000000000001375
- PMID
- 27482962
- PMCID
- PMC5288378
- ISSN
- 0041-1337
- eISSN
- 1534-6080
- Number of pages
- 6
- Grant note
- Dr. Adam Linton Chair in Kidney Analytics Pfizer KRESCENT New Investigator Award; Canadian Institutes of Health Research (CIHR) CIHR; Canadian Institutes of Health Research (CIHR) Astellas; Astellas Pharmaceuticals R01DK096008 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) R01-DK096008 / National Institutes of Health (NIH)/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) Roche; Roche Holding
- Language
- English
- Date published
- 06/01/2017
- Academic Unit
- Surgery
- Record Identifier
- 9984322950702771
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