Diabetes, Obesity, and the Metabolic Syndrome as Prognostic Factors in Stages I to III Colorectal Cancer Patients

Brianna Croft; Melissa Reed; Caitlyn Patrick; Natalie Kovacevich; Ioannis A Voutsadakis

doi:10.1007/s12029-018-0056-9

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Diabetes, Obesity, and the Metabolic Syndrome as Prognostic Factors in Stages I to III Colorectal Cancer Patients

Journal article

Peer reviewed

Diabetes, Obesity, and the Metabolic Syndrome as Prognostic Factors in Stages I to III Colorectal Cancer Patients

Brianna Croft, Melissa Reed, Caitlyn Patrick, Natalie Kovacevich and Ioannis A Voutsadakis

Journal of gastrointestinal cancer, Vol.50(2), pp.221-229

06/15/2019

DOI: 10.1007/s12029-018-0056-9

PMID: 29335847

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Abstract

Attempts to introduce prognostic factors for survival outcomes in localized colorectal cancer patients receiving surgical treatment with or without adjuvant therapies, beyond the classic staging parameters, have been met with limited success. Obesity and diabetes mellitus are among the conditions that predispose to colorectal cancer but their value as prognostic markers once the disease is diagnosed is controversial. This study examines the prognostic value of the components of metabolic syndrome in a retrospective series of colorectal cancer patients with stages I to III disease followed in a single center. Among the four components of the metabolic syndrome, only diabetes was independently associated with progression-free survival (PFS) while obesity, hypertension, and dyslipidemia were not. No associations of the metabolic syndrome (MS) or its components with overall survival (OS) were observed in multivariate analysis. These data pinpoint to diabetes mellitus (DM) as a possible prognostic factor for PFS in localized colorectal cancer and further cast doubt for the value of obesity as measured by body mass index (BMI) on local stage colorectal cancer prognosis.

Aged

Body Mass Index

Colorectal Neoplasms - mortality

Colorectal Neoplasms - pathology

Colorectal Neoplasms - physiopathology

Colorectal Neoplasms - surgery

Diabetes Complications - pathology

Diabetes Complications - physiopathology

Disease-Free Survival

Female

Humans

Male

Metabolic Syndrome - pathology

Metabolic Syndrome - physiopathology

Neoplasm Staging

Obesity - pathology

Obesity - physiopathology

Prognosis

Retrospective Studies

Survival Rate

Details

Title: Subtitle: Diabetes, Obesity, and the Metabolic Syndrome as Prognostic Factors in Stages I to III Colorectal Cancer Patients
Creators: Brianna Croft - Sault Area Hospital
Melissa Reed - Sault Area Hospital
Caitlyn Patrick - Sault Area Hospital
Natalie Kovacevich - Sault Area Hospital
Ioannis A Voutsadakis - NOSM University
Resource Type: Journal article
Publication Details: Journal of gastrointestinal cancer, Vol.50(2), pp.221-229
DOI: 10.1007/s12029-018-0056-9
PMID: 29335847
ISSN: 1941-6628
eISSN: 1941-6636
Language: English
Date published: 06/15/2019
Academic Unit: Internal Medicine
Record Identifier: 9984806607402771

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