Journal article
Diabetes mellitus and birth defects
American journal of obstetrics and gynecology, Vol.199(3), pp.237.e1-237.e9
2008
DOI: 10.1016/j.ajog.2008.06.028
PMCID: PMC4916956
PMID: 18674752
Abstract
The purpose of this study was to examine associations between diabetes mellitus and 39 birth defects.
This was a multicenter case-control study of mothers of infants who were born with (n = 13,030) and without (n = 4895) birth defects in the National Birth Defects Prevention Study (1997-2003).
Pregestational diabetes mellitus (PGDM) was associated significantly with noncardiac defects (isolated, 7/23 defects; multiples, 13/23 defects) and cardiac defects (isolated, 11/16 defects; multiples, 8/16 defects). Adjusted odds ratios for PGDM and all isolated and multiple defects were 3.17 (95% CI, 2.20-4.99) and 8.62 (95% CI, 5.27-14.10), respectively. Gestational diabetes mellitus (GDM) was associated with fewer noncardiac defects (isolated, 3/23 defects; multiples, 3/23 defects) and cardiac defects (isolated, 3/16 defects; multiples, 2/16 defects). Odds ratios between GDM and all isolated and multiple defects were 1.42 (95% CI, 1.17-1.73) and 1.50 (95% CI, 1.13-2.00), respectively. These associations were limited generally to offspring of women with prepregnancy body mass index ≥25 kg/m
2.
PGDM was associated with a wide range of birth defects; GDM was associated with a limited group of birth defects.
Details
- Title: Subtitle
- Diabetes mellitus and birth defects
- Creators
- Adolfo Correa - Division of Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GASuzanne M Gilboa - Division of Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GALilah M Besser - Division of Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GALorenzo D Botto - Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UTCynthia A Moore - Division of Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GACharlotte A Hobbs - Department of Pediatrics, Birth Defects Research Section, University of Arkansas for Medical Sciences and Arkansas Children's Hospital Research Institute, Little Rock, ARMario A Cleves - Department of Pediatrics, Birth Defects Research Section, University of Arkansas for Medical Sciences and Arkansas Children's Hospital Research Institute, Little Rock, ARTiffany J Riehle-Colarusso - Division of Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GAD. Kim Waller - School of Public Health, University of Texas Health Science Center at Houston, Houston, TXE. Albert Reece - University of Maryland School of Medicine, Baltimore, MDNational Birth Defects Prevention Study
- Contributors
- Paul A Romitti (Contributor) - University of Iowa, Epidemiology
- Resource Type
- Journal article
- Publication Details
- American journal of obstetrics and gynecology, Vol.199(3), pp.237.e1-237.e9
- DOI
- 10.1016/j.ajog.2008.06.028
- PMID
- 18674752
- PMCID
- PMC4916956
- NLM abbreviation
- Am J Obstet Gynecol
- ISSN
- 0002-9378
- eISSN
- 1097-6868
- Publisher
- Mosby, Inc
- Language
- English
- Date published
- 2008
- Academic Unit
- Epidemiology; Biostatistics
- Record Identifier
- 9984214674002771
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