Diabetes mellitus exacerbates motor and sensory impairment in CMT1A

Soham Sheth; Kevin Francies; Carly E Siskind; Shawna M E Feely; Richard A Lewis; Michael E Shy

doi:10.1111/j.1529-8027.2008.00196.x

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Diabetes mellitus exacerbates motor and sensory impairment in CMT1A

Journal article

Peer reviewed

Diabetes mellitus exacerbates motor and sensory impairment in CMT1A

Soham Sheth, Kevin Francies, Carly E Siskind, Shawna M E Feely, Richard A Lewis and Michael E Shy

Journal of the peripheral nervous system, Vol.13(4), pp.299-304

12/2008

DOI: 10.1111/j.1529-8027.2008.00196.x

PMID: 19192070

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Abstract

Charcot-Marie-Tooth disease type 1A (CMT1A) is caused by a duplication of PMP22 on chromosome 17 and is the most commonly inherited demyelinating neuropathy. Diabetes frequently causes predominantly sensory neuropathy. Whether diabetes exacerbates CMT1A is unknown. We identified 10 patients with CMT1A and diabetes and compared their impairment with 48 age-matched control patients with CMT1A alone. Comparisons were made with the Charcot-Marie-Tooth disease (CMT) neuropathy score (CMTNS) and by electrophysiology. The CMTNS was significantly higher in patients with diabetes (20.25 +/- 2.35) compared with controls (15.19 +/- 0.69; p = 0.01). Values were particularly higher for motor signs and symptoms. Seven of the 10 diabetic patients had CMTNS >20 (severe CMT), while only 7 of the 48 age-matched controls had scores >20. There was a trend for CMT1A patients with diabetes to have low compound muscle action potentials and sensory nerve action potentials, although nerve conduction velocities were not slower in diabetic patients compared with controls. Diabetes was associated with more severe motor and sensory impairment in patients with CMT1A.

Action Potentials - physiology

Charcot-Marie-Tooth Disease - complications

Humans

Electrophysiology

Adult

Female

Male

Neural Conduction - physiology

Charcot-Marie-Tooth Disease - physiopathology

Diabetes Mellitus, Type 1 - complications

Diabetes Mellitus, Type 2 - complications

Details

Title: Subtitle: Diabetes mellitus exacerbates motor and sensory impairment in CMT1A
Creators: Soham Sheth - Department of Neurology, Wayne State University, Detroit, MI 48201, USA
Kevin Francies
Carly E Siskind
Shawna M E Feely
Richard A Lewis
Michael E Shy
Resource Type: Journal article
Publication Details: Journal of the peripheral nervous system, Vol.13(4), pp.299-304
DOI: 10.1111/j.1529-8027.2008.00196.x
PMID: 19192070
NLM abbreviation: J Peripher Nerv Syst
ISSN: 1085-9489
eISSN: 1529-8027
Publisher: United States
Language: English
Date published: 12/2008
Academic Unit: Neurology; Molecular Physiology and Biophysics; Stead Family Department of Pediatrics; Iowa Neuroscience Institute
Record Identifier: 9984013926702771

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