Diabetes mellitus is associated with increased acute kidney injury and 1‐year mortality after transcatheter aortic valve replacement: A meta‐analysis

George S. Mina; Priyanka Gill; Demiana Soliman; Pratap Reddy; Paari Dominic

doi:10.1002/clc.22723

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Diabetes mellitus is associated with increased acute kidney injury and 1‐year mortality after transcatheter aortic valve replacement: A meta‐analysis

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Diabetes mellitus is associated with increased acute kidney injury and 1‐year mortality after transcatheter aortic valve replacement: A meta‐analysis

George S. Mina, Priyanka Gill, Demiana Soliman, Pratap Reddy and Paari Dominic

Clinical cardiology (Mahwah, N.J.), Vol.40(9), pp.726-731

05/16/2017

DOI: 10.1002/clc.22723

PMCID: PMC6490528

PMID: 28510272

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Abstract

Background: Diabetes mellitus (DM) is associated with adverse outcomes after surgical aortic valve replacement. However, there are conflicting data on the impact of DM on outcomes of transcatheter aortic valve replacement (TAVR). Hypothesis: DM is associated with poor outcomes after different cardiac procedures. Therefore, DM can also be associated with poor outcomes after TAVR. Methods: We searched PubMed and Cochrane Central Register of Controlled Trials for studies that evaluated outcomes after TAVR and stratified at least 1 of the studied endpoints by DM status. The primary endpoint was all-cause mortality at 1 year. Secondary endpoints were early (up to 30 days) mortality, acute kidney injury (AKI), cerebrovascular accident (CVA), major bleeding, and major vascular complications. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using random effects models. Results: We included 64 studies with a total of 38 686 patients. DM was associated with significantly higher 1-year mortality (OR: 1.14, 95% CI: 1.04-1.26, P = 0.008) and periprocedural AKI (OR: 1.28, 95% CI: 1.08-1.52, P = 0.004). On the other hand, there were no significant differences between diabetics and nondiabetics in early mortality, CVAs, major bleeding, or major vascular complications. Conclusions: DM is associated with increased 1-year mortality and periprocedural AKI in patients undergoing TAVR. The results of this study suggest that DM is a predictor of adverse outcomes in patients undergoing TAVR.

Clinical Investigations

Diabetes Mellitus

Meta‐analysis

Transcatheter Aortic Valve Replacement

Details

Title: Subtitle: Diabetes mellitus is associated with increased acute kidney injury and 1‐year mortality after transcatheter aortic valve replacement: A meta‐analysis
Creators: George S. Mina - Louisiana State University Health Sciences Center Shreveport
Priyanka Gill - Louisiana State University Health Sciences Center Shreveport
Demiana Soliman - Louisiana State University Health Sciences Center Shreveport
Pratap Reddy - Louisiana State University Health Sciences Center Shreveport
Paari Dominic - Louisiana State University Health Sciences Center Shreveport
Resource Type: Journal article
Publication Details: Clinical cardiology (Mahwah, N.J.), Vol.40(9), pp.726-731
DOI: 10.1002/clc.22723
PMID: 28510272
PMCID: PMC6490528
NLM abbreviation: Clin Cardiol
ISSN: 0160-9289
eISSN: 1932-8737
Publisher: Wiley Periodicals, Inc
Alternative title: Impact of Diabetes on TAVR outcomes
Language: English
Date published: 05/16/2017
Academic Unit: Internal Medicine
Record Identifier: 9984367255802771

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