Diabetic cardiomyopathy, causes and effects

Sihem Boudina; Evan Dale Abel

doi:10.1007/s11154-010-9131-7

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Diabetic cardiomyopathy, causes and effects

Journal article

Peer reviewed

Diabetic cardiomyopathy, causes and effects

Sihem Boudina and Evan Dale Abel

Reviews in endocrine & metabolic disorders, Vol.11(1), pp.31-39

03/2010

DOI: 10.1007/s11154-010-9131-7

PMCID: PMC2914514

PMID: 20180026

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http://doi.org/10.1007/s11154-010-9131-7View

Open Access

Abstract

Diabetes is associated with increased incidence of heart failure even after controlling for coronary artery disease and hypertension. Thus, as diabetic cardiomyopathy has become an increasingly recognized entity among clinicians, a better understanding of its pathophysiology is necessary for early diagnosis and the development of treatment strategies for diabetes-associated cardiovascular dysfunction. We will review recent basic and clinical research into the manifestations and the pathophysiological mechanisms of diabetic cardiomyopathy. The discussion will be focused on the structural, functional and metabolic changes that occur in the myocardium in diabetes and how these changes may contribute to the development of diabetic cardiomyopathy in affected humans and relevant animal models.

Fatty Acids - adverse effects

Diabetes Complications

Oxidative Stress

Obesity - complications

Humans

Hypertrophy, Left Ventricular - etiology

Male

Myocardium - pathology

Cardiomyopathies - etiology

Necrosis

Heart Failure, Diastolic - etiology

Mitochondria, Heart - physiology

Hypertrophy, Left Ventricular - complications

Fibrosis

Female

Details

Title: Subtitle: Diabetic cardiomyopathy, causes and effects
Creators: Sihem Boudina - Division of Endocrinology Metabolism and Diabetes, Program in Molecular Medicine, University of Utah School of Medicine, 15 North 2030 East, Bldg. 533 Room 3110B, Salt Lake City, UT 84112, USA
Evan Dale Abel
Resource Type: Journal article
Publication Details: Reviews in endocrine & metabolic disorders, Vol.11(1), pp.31-39
DOI: 10.1007/s11154-010-9131-7
PMID: 20180026
PMCID: PMC2914514
NLM abbreviation: Rev Endocr Metab Disord
ISSN: 1389-9155
eISSN: 1573-2606
Publisher: Germany
Grant note: P30 HL101310-01 / NHLBI NIH HHS P30 HL101310 / NHLBI NIH HHS U01 HL087947-04 / NHLBI NIH HHS R01 DK092065 / NIDDK NIH HHS U01 HL087947 / NHLBI NIH HHS
Language: English
Date published: 03/2010
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology; Endocrinology and Metabolism; Internal Medicine
Record Identifier: 9984024403202771

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