Diabetic cardiomyopathy revisited

Sihem Boudina; E Dale Abel

doi:10.1161/CIRCULATIONAHA.106.679597

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Journal article

Open access

Peer reviewed

Diabetic cardiomyopathy revisited

Sihem Boudina and E Dale Abel

Circulation (New York, N.Y.), Vol.115(25), pp.3213-3223

06/26/2007

DOI: 10.1161/CIRCULATIONAHA.106.679597

PMID: 17592090

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Abstract

Diabetes mellitus increases the risk of heart failure independently of underlying coronary artery disease, and many believe that diabetes leads to cardiomyopathy. The underlying pathogenesis is partially understood. Several factors may contribute to the development of cardiac dysfunction in the absence of coronary artery disease in diabetes mellitus. This review discusses the latest findings in diabetic humans and in animal models and reviews emerging new mechanisms that may be involved in the development and progression of cardiac dysfunction in diabetes.

Diastole

Oxidative Stress

Calcium - metabolism

Humans

Heart Failure - physiopathology

Homeostasis

Cardiomyopathies - prevention & control

Cardiomyopathies - etiology

Heart Failure - prevention & control

Fatty Acids, Nonesterified - metabolism

Cardiomyopathies - physiopathology

Mice, Mutant Strains

Diabetes Complications - epidemiology

Models, Animal

Diabetes Mellitus, Experimental - complications

Heart Failure - epidemiology

Heart Failure - etiology

Diabetes Complications - prevention & control

Diabetes Mellitus, Experimental - physiopathology

Diabetes Complications - physiopathology

Rats

Ventricular Dysfunction, Left - etiology

Renin-Angiotensin System - physiology

Ventricular Dysfunction, Left - physiopathology

Rats, Zucker

Cardiomyopathies - epidemiology

Animals

Mitochondria, Heart - physiology

Mice

PPAR alpha - metabolism

Details

Title: Subtitle: Diabetic cardiomyopathy revisited
Creators: Sihem Boudina - Division of Endocrinology, Metabolism and Diabetes and Program in Human Molecular Biology and Genetics, University of Utah School of Medicine, Salt Lake City 84112, USA
E Dale Abel
Resource Type: Journal article
Publication Details: Circulation (New York, N.Y.), Vol.115(25), pp.3213-3223
DOI: 10.1161/CIRCULATIONAHA.106.679597
PMID: 17592090
NLM abbreviation: Circulation
ISSN: 0009-7322
eISSN: 1524-4539
Publisher: Lippincott Williams & Wilkins; United States
Grant note: U01HL70525 / NHLBI NIH HHS R01 HL73167 / NHLBI NIH HHS R01 HL70070 / NHLBI NIH HHS U01 HL087947 / NHLBI NIH HHS
Language: English
Date published: 06/26/2007
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology; Endocrinology and Metabolism; Internal Medicine
Record Identifier: 9984024553802771

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