Journal article
Diagnosis and Detection of Sarcoidosis An Official American Thoracic Society Clinical Practice Guideline
American journal of respiratory and critical care medicine, Vol.201(8), pp.E26-E51
04/15/2020
DOI: 10.1164/rccm.202002-0251ST
PMCID: PMC7159433
PMID: 32293205
Abstract
Background: The diagnosis of sarcoidosis is not standardized but is based on three major criteria: a compatible clinical presentation, finding nonnecrotizing granulomatous inflammation in one or more tissue samples, and the exclusion of alternative causes of granulomatous disease. There are no universally accepted measures to determine if each diagnostic criterion has been satisfied; therefore, the diagnosis of sarcoidosis is never fully secure.
Methods: Systematic reviews and, when appropriate, meta-analyses were performed to summarize the best available evidence. The evidence was appraised using the Grading of Recommendations, Assessment, Development, and Evaluation approach and then discussed by a multidisciplinary panel. Recommendations for or against various diagnostic tests were formulated and graded after the expert panel weighed desirable and undesirable consequences, certainty of estimates, feasibility, and acceptability.
Results: The clinical presentation, histopathology, and exclusion of alternative diagnoses were summarized. On the basis of the available evidence, the expert committee made 1 strong recommendation for baseline serum calcium testing, 13 conditional recommendations, and 1 best practice statement. All evidence was very low quality.
Conclusions: The panel used systematic reviews of the evidence to inform clinical recommendations in favor of or against various diagnostic tests in patients with suspected or known sarcoidosis. The evidence and recommendations should be revisited as new evidence becomes available.
Details
- Title: Subtitle
- Diagnosis and Detection of Sarcoidosis An Official American Thoracic Society Clinical Practice Guideline
- Creators
- Elliott D. Crouser - The Ohio State UniversityLisa A. Maier - University of Occupational and Environmental Health JapanKevin C. Wilson - Boston UniversityCatherine A. Bonham - University of VirginiaAdam S. Morgenthau - Icahn School of Medicine at Mount SinaiKaren C. Patterson - Brighton and Sussex Medical SchoolEric Abston - Boston UniversityRichard C. Bernstein - Penn State Milton S. Hershey Medical CenterRon Blankstein - Harvard UniversityEdward S. Chen - Vanderbilt UniversityDaniel A. Culver - Cleveland ClinicWonder Drake - Vanderbilt UniversityMarjolein Drent - Ild Care FoundationAlicia K. Gerke - University of IowaMichael Ghobrial - Cleveland ClinicPraveen Govender - Boston UniversityNabeel Hamzeh - University of IowaW. Ennis James - Medical University of South CarolinaMarc A. Judson - Albany Medical Center HospitalLiz Kellermeyer - University of DenverShandra Knight - University of DenverLaura L. Koth - University of California, San FranciscoVenerino Poletti - Aarhus UniversitySubha Raman - The Ohio State UniversityMelissa H. Tukey - Kaiser PermanenteGloria E. Westney - Morehouse School of MedicineRobert P. Baughman - University of CincinnatiAmerican Thoracic Society Assembly on Clinical Problems
- Resource Type
- Journal article
- Publication Details
- American journal of respiratory and critical care medicine, Vol.201(8), pp.E26-E51
- DOI
- 10.1164/rccm.202002-0251ST
- PMID
- 32293205
- PMCID
- PMC7159433
- NLM abbreviation
- Am J Respir Crit Care Med
- ISSN
- 1073-449X
- eISSN
- 1535-4970
- Publisher
- Amer Thoracic Soc
- Number of pages
- 26
- Grant note
- American Thoracic Society
- Language
- English
- Date published
- 04/15/2020
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; Internal Medicine
- Record Identifier
- 9984359661002771
Metrics
18 Record Views