Journal article
Diagnosis and treatment of impulse control disorders in patients with movement disorders
Therapeutic advances in neurological disorders, Vol.6(3), pp.175-188
05/2013
DOI: 10.1177/1756285613476127
PMCID: PMC3625015
PMID: 23634190
Abstract
Impulse control disorders are a psychiatric condition characterized by the failure to resist an impulsive act or behavior that may be harmful to self or others. In movement disorders, impulse control disorders are associated with dopaminergic treatment, notably dopamine agonists (DAs). Impulse control disorders have been studied extensively in Parkinson’s disease, but are also recognized in restless leg syndrome and atypical Parkinsonian syndromes. Epidemiological studies suggest younger age, male sex, greater novelty seeking, impulsivity, depression and premorbid impulse control disorders as the most consistent risk factors. Such patients may warrant special monitoring after starting treatment with a DA. Various individual screening tools are available for people without Parkinson’s disease. The Questionnaire for Impulsive-Compulsive Disorders in Parkinson’s Disease has been developed specifically for Parkinson’s disease. The best treatment for impulse control disorders is prevention. However, after the development of impulse control disorders, the mainstay intervention is to reduce or discontinue the offending anti-Parkinsonian medication. In refractory cases, other pharmacological interventions are available, including neuroleptics, antiepileptics, amantadine, antiandrogens, lithium and opioid antagonists. Unfortunately, their use is only supported by case reports, small case series or open-label clinical studies. Prospective, controlled studies are warranted. Ongoing investigations include naltrexone and nicotine.
Details
- Title: Subtitle
- Diagnosis and treatment of impulse control disorders in patients with movement disorders
- Creators
- Tiago A Mestre - Movement Disorders Centre and the Edmond J. Safra Program in Parkinson’s Disease, Toronto Western Hospital, University Health Network, Division of Neurology, University of Toronto, Toronto, Ontario, CanadaAntonio P Strafella - Movement Disorders Centre and the Edmond J. Safra Program in Parkinson’s Disease, Toronto Western Hospital, University Health Network, Division of Neurology, University of Toronto, Toronto, Ontario, CanadaTeri Thomsen - Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USAValerie Voon - Behavioral and Clinical Neurosciences Institute, University of Cambridge, Cambridge, EnglandJanis Miyasaki - Movement Disorder Clinic, Toronto Western Hospital, 399 Bathurst Street, MC-7 402, Toronto, Ontario, Canada M5T 2S8
- Resource Type
- Journal article
- Publication Details
- Therapeutic advances in neurological disorders, Vol.6(3), pp.175-188
- DOI
- 10.1177/1756285613476127
- PMID
- 23634190
- PMCID
- PMC3625015
- NLM abbreviation
- Ther Adv Neurol Disord
- ISSN
- 1756-2856
- eISSN
- 1756-2864
- Publisher
- SAGE Publications; Sage UK: London, England
- Language
- English
- Date published
- 05/2013
- Academic Unit
- Neurology
- Record Identifier
- 9984020725302771
Metrics
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