Diagnostic Performance of PET and Perfusion-Weighted malting in Differentiating Tumor Recurrence or Progression from Radiation Necrosis in Posttreatment Gliomas: A Review of Literature

N. Soni; M. Ora; N. Mohindra; Y. Menda; G. Bathla

doi:10.3174/ajnr.A6685

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Diagnostic Performance of PET and Perfusion-Weighted malting in Differentiating Tumor Recurrence or Progression from Radiation Necrosis in Posttreatment Gliomas: A Review of Literature

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Diagnostic Performance of PET and Perfusion-Weighted malting in Differentiating Tumor Recurrence or Progression from Radiation Necrosis in Posttreatment Gliomas: A Review of Literature

N. Soni, M. Ora, N. Mohindra, Y. Menda and G. Bathla

American journal of neuroradiology : AJNR, Vol.41(9), pp.1550-1557

09/01/2020

DOI: 10.3174/ajnr.A6685

PMCID: PMC7583093

PMID: 32855194

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Abstract

Tumor resection followed by chemoradiation remains the current criterion standard treatment for high-grade gliomas. Regardless of aggressive treatment, tumor recurrence and radiation necrosis are 2 different outcomes. Differentiation of tumor recurrence from radiation necrosis remains a critical problem in these patients because of considerable overlap in clinical and imaging presentations. Contrast-enhanced MR imaging is the universal imaging technique for diagnosis, treatment evaluation, and detection of recurrence of high-grade gliomas. PWI and PET with novel radiotracers have an evolving role for monitoring treatment response in high-grade gliomas. In the literature, there is no clear consensus on the superiority of either technique or their complementary information. This review aims to elucidate the diagnostic performance of individual and combined use of functional (PWI) and metabolic (PET) imaging modalities to distinguish recurrence from posttreatment changes in gliomas.

Clinical Neurology

Life Sciences & Biomedicine

Neuroimaging

Neurosciences & Neurology

Radiology, Nuclear Medicine & Medical Imaging

Science & Technology

Details

Title: Subtitle: Diagnostic Performance of PET and Perfusion-Weighted malting in Differentiating Tumor Recurrence or Progression from Radiation Necrosis in Posttreatment Gliomas: A Review of Literature
Creators: N. Soni - University of Iowa Hospitals and Clinics
M. Ora - Sanjay Gandhi Post Graduate Institute of Medical Sciences
N. Mohindra - Sanjay Gandhi Post Graduate Institute of Medical Sciences
Y. Menda - University of Iowa Hospitals and Clinics
G. Bathla - University of Iowa
Resource Type: Journal article
Publication Details: American journal of neuroradiology : AJNR, Vol.41(9), pp.1550-1557
DOI: 10.3174/ajnr.A6685
PMID: 32855194
PMCID: PMC7583093
NLM abbreviation: AJNR Am J Neuroradiol
ISSN: 0195-6108
eISSN: 1936-959X
Publisher: Amer Soc Neuroradiology
Number of pages: 8
Language: English
Date published: 09/01/2020
Academic Unit: Radiology; Radiation Oncology
Record Identifier: 9984312969502771

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