Diagnostic Performance of Prostate Multiparametric Magnetic Resonance Imaging in African-American Men

Grant M Henning; Joel M Vetter; Bettina F Drake; Joseph E Ippolito; Anup S Shetty; Gerald L Andriole; Eric H Kim

doi:10.1016/j.urology.2019.08.007

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Diagnostic Performance of Prostate Multiparametric Magnetic Resonance Imaging in African-American Men

Journal article

Peer reviewed

Diagnostic Performance of Prostate Multiparametric Magnetic Resonance Imaging in African-American Men

Grant M Henning, Joel M Vetter, Bettina F Drake, Joseph E Ippolito, Anup S Shetty, Gerald L Andriole and Eric H Kim

Urology (Ridgewood, N.J.), Vol.134, pp.181-185

12/2019

DOI: 10.1016/j.urology.2019.08.007

PMID: 31419432

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Abstract

To compare test performance of multiparametric magnetic resonance imaging (mpMRI) for detection of prostate cancer (PCa) in African-American men (AAM) and white men (WM) using the Prostate Imaging Reporting and Data System in unmatched groups as well as a cohort matched for clinical factors. We examined our database of men who underwent prostate mpMRI prior to biopsy between October 2014 and June 2017 (n = 601; 60 AAM, 541 WM). Test performance was defined using Prostate Imaging Reporting and Data System classification 4 or 5 considered test positive and Gleason grade group 2 or greater from any biopsy core considered outcome positive. A subset analysis was performed using a propensity score caliper matching algorithm to match AAM to WM in a 1:2 ratio using the variables age, PSA, and PSA density. No significant differences in test performance were found with similar sensitivity (86.7% vs 83.6, P = 1.00), specificity (45.9% vs 49.1%, P = .71), positive predictive value (50.0% vs 46.9%), and negative predictive value (85.0% vs 84.8%, P = 1.00) for AAM and WM. Similar results were noted in our matched comparison. The rate of upgrading between targeted and systematic biopsy cores did not statistically differ between AAM and WM in both unmatched (12.2% vs. 15.8%, P = .66) and matched (12.2% vs 12.8%, P = .92) comparisons. Our findings provide supporting evidence that AAM have similar outcomes to WM in PCa detection using mpMRI. We suggest that mpMRI should not be withheld or offered preferentially on the basis of race when used for the detection of PCa.

African Americans

Aged

Algorithms

Biopsy, Needle

European Continental Ancestry Group

Humans

Image-Guided Biopsy

Male

Middle Aged

Multiparametric Magnetic Resonance Imaging

Neoplasm Grading

Predictive Value of Tests

Propensity Score

Prostate-Specific Antigen - blood

Prostatic Neoplasms - diagnostic imaging

Prostatic Neoplasms - pathology

Sensitivity and Specificity

Ultrasonography

Details

Title: Subtitle: Diagnostic Performance of Prostate Multiparametric Magnetic Resonance Imaging in African-American Men
Creators: Grant M Henning - Washington University in St. Louis
Joel M Vetter - Washington University in St. Louis
Bettina F Drake - Washington University in St. Louis
Joseph E Ippolito - Washington University in St. Louis
Anup S Shetty - Washington University in St. Louis
Gerald L Andriole - Washington University in St. Louis
Eric H Kim - Washington University in St. Louis
Resource Type: Journal article
Publication Details: Urology (Ridgewood, N.J.), Vol.134, pp.181-185
DOI: 10.1016/j.urology.2019.08.007
PMID: 31419432
NLM abbreviation: Urology
ISSN: 0090-4295
eISSN: 1527-9995
Language: English
Date published: 12/2019
Academic Unit: Urology
Record Identifier: 9984949472102771

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