Diagnostic Yield of FDG-PET/CT, MRI, and CSF Cytology in Non-Biopsiable Neurolymphomatosis as a Heralding Sign of Recurrent Non-Hodgkin's Lymphoma

Faiq Shaikh; Aubrey C Chan; Omer Awan; Nivedita Jerath; Chandan Reddy; Salman A Khan; Michael M Graham

doi:10.7759/cureus.319

Back

Diagnostic Yield of FDG-PET/CT, MRI, and CSF Cytology in Non-Biopsiable Neurolymphomatosis as a Heralding Sign of Recurrent Non-Hodgkin's Lymphoma

Journal article

Open access

Peer reviewed

Diagnostic Yield of FDG-PET/CT, MRI, and CSF Cytology in Non-Biopsiable Neurolymphomatosis as a Heralding Sign of Recurrent Non-Hodgkin's Lymphoma

Faiq Shaikh, Aubrey C Chan, Omer Awan, Nivedita Jerath, Chandan Reddy, Salman A Khan and Michael M Graham

Curēus (Palo Alto, CA), Vol.7(9), p.e319

09/09/2015

DOI: 10.7759/cureus.319

PMCID: PMC4601979

PMID: 26487995

Files and links (1)

url

https://doi.org/10.7759/cureus.319View

Published (Version of record) Open Access

Abstract

Neurolymphomatosis (NL) is a rare condition associated with lymphomas in which various structures of the nervous system are infiltrated by malignant lymphocytes. Rarely, it may be the presenting feature of recurrence of lymphoma otherwise deemed to be in remission. It is crucial, as is the case with all types of nodal or visceral involvement of lymphoma, to identify the disease early and initiate treatment with chemotherapy and/or radiation therapy. Positron emission tomography-computed tomography (PET-CT) has been shown to be a sensitive modality for staging, restaging, biopsy guidance, therapy response assessment, and surveillance for recurrence of lymphoma. Magnetic resonance imaging (MRI) is another useful imaging modality, which, along with PET/CT, compliment cerebrospinal spinal fluid (CSF) cytology and electromyography (EMG) in the diagnosis of NL. Performing nerve biopsies to confirm neurolymphomatosis can be challenging and with associated morbidity. The case presented herein illustrates the practical usefulness of these tests in detecting NL as a heralding feature of lymphoma recurrence, especially in the absence of histopathologic correlation.

csf cytology

diffuse large b-cell lymphoma (dlbcl)

fdg

mri

Neurology

neurolymphomatosis

non-hodgkin's lymphoma

Oncology

pet-ct

Radiology

Details

Title: Subtitle: Diagnostic Yield of FDG-PET/CT, MRI, and CSF Cytology in Non-Biopsiable Neurolymphomatosis as a Heralding Sign of Recurrent Non-Hodgkin's Lymphoma
Creators: Faiq Shaikh - University of Pittsburgh Medical Center
Aubrey C Chan - University of Iowa
Omer Awan - Dartmouth–Hitchcock Medical Center
Nivedita Jerath - University of Iowa Hospitals and Clinics
Chandan Reddy - University of Iowa
Salman A Khan - University of Missouri–Kansas City
Michael M Graham - University of Iowa
Resource Type: Journal article
Publication Details: Curēus (Palo Alto, CA), Vol.7(9), p.e319
DOI: 10.7759/cureus.319
PMID: 26487995
PMCID: PMC4601979
NLM abbreviation: Cureus
ISSN: 2168-8184
eISSN: 2168-8184
Publisher: Cureus
Language: English
Date published: 09/09/2015
Academic Unit: Radiology; Psychiatry; Radiation Oncology; Neurosurgery; Internal Medicine
Record Identifier: 9984281659302771

Metrics

20 Record Views

11 Times Cited - Web of Science

See more details