Journal article
Diagnostic challenge: Juvenile bullous pemphigoid with a negative BP180 ELISA
Pediatric dermatology, Vol.42(2), pp.342-345
03/2025
DOI: 10.1111/pde.15741
PMCID: PMC11950797
PMID: 39168501
Appears in UI Libraries Support Open Access
Abstract
Bullous pemphigoid (BP) is an autoimmune blistering disease primarily affecting the elderly, whereas cases of juvenile BP are rare. Both types of BP are typically mediated by autoantibodies targeting the NC16A region of BP180; however, a small subset of adult patient sera react to other regions of the protein. The incidence of a similar occurrence in juvenile BP is unknown. This case of juvenile BP with a negative BP180 ELISA highlights diagnostic pitfalls that can lead to a delay in the correct diagnosis in the pediatric population.Bullous pemphigoid (BP) is an autoimmune blistering disease primarily affecting the elderly, whereas cases of juvenile BP are rare. Both types of BP are typically mediated by autoantibodies targeting the NC16A region of BP180; however, a small subset of adult patient sera react to other regions of the protein. The incidence of a similar occurrence in juvenile BP is unknown. This case of juvenile BP with a negative BP180 ELISA highlights diagnostic pitfalls that can lead to a delay in the correct diagnosis in the pediatric population.
Details
- Title: Subtitle
- Diagnostic challenge: Juvenile bullous pemphigoid with a negative BP180 ELISA
- Creators
- Janet A Fairley - University of IowaKristen G Berrebi - University of IowaAndrew M Poggemiller - University of IowaAfshin Varzavand - University of Iowa, DermatologyKelly N Messingham
- Resource Type
- Journal article
- Publication Details
- Pediatric dermatology, Vol.42(2), pp.342-345
- DOI
- 10.1111/pde.15741
- PMID
- 39168501
- PMCID
- PMC11950797
- NLM abbreviation
- Pediatr Dermatol
- ISSN
- 1525-1470
- eISSN
- 1525-1470
- Publisher
- Wiley
- Grant note
University of Iowa Department of Dermatology
- Language
- English
- Electronic publication date
- 08/21/2024
- Date published
- 03/2025
- Academic Unit
- Dermatology; Stead Family Department of Pediatrics; Surgery
- Record Identifier
- 9984699521702771
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