Journal article
Diagnostic criteria for enduring sexual dysfunction after treatment with antidepressants, finasteride and isotretinoin
The International journal of risk & safety in medicine, Vol.33(1), pp.65-76
01/01/2022
DOI: 10.3233/JRS-210023
PMCID: PMC8925105
PMID: 34719438
Abstract
BACKGROUND: A set of enduring conditions have been reported in the literature involving persistent sexual dysfunction after discontinuation of serotonin reuptake inhibiting antidepressants, 5 alpha-reductase inhibitors and isotretinoin.
OBJECTIVE: To develop diagnostic criteria for post-SSRI sexual dysfunction (PSSD), persistent genital arousal disorder (PGAD) following serotonin reuptake inhibitors, post-finasteride syndrome (PFS) and post-retinoid sexual dysfunction (PRSD).
METHODS: The original draft was designed using data from two published case series (Hogan et al., 2014 and Healy et al., 2018), which represent the largest public collections of data on these enduring conditions. It was further developed with the involvement of a multidisciplinary panel of experts.
RESULTS: A set of criteria were agreed upon for each of the above conditions. Features of PSSD, PFS and PRSD commonly include decreased genital and orgasmic sensation, decreased sexual desire and erectile dysfunction. Ancillary non-sexual symptoms vary depending on the specific condition but can include emotional blunting and cognitive impairment. PGAD presents with an almost mirror image of unwanted sensations of genital arousal or irritability in the absence of sexual desire. A new term, post-S SRI asexuality, is introduced to describe a dampening of sexual interest and pleasure resulting from a pre-natal or pre-teen exposure to a serotonin reuptake inhibitor.
CONCLUSIONS: These criteria will help in both clinical and research settings. As with all criteria, they will likely need modification in the light of developments.
Details
- Title: Subtitle
- Diagnostic criteria for enduring sexual dysfunction after treatment with antidepressants, finasteride and isotretinoin
- Creators
- David Healy - McMaster UniversityAudrey Bahrick - University of IowaMaarten Bak - Maastricht UniversityAngelo Barbato - Mario Negri Institute for Pharmacological ResearchRocco Salvatore Calabro - Centro Neurolesi Bonino PulejoBarbara M. Chubak - Icahn School of Medicine at Mount SinaiFiammetta Cosci - Maastricht UniversityAntonei B. Csoka - Howard UniversityBarbara D'Avanzo - Mario Negri Institute for Pharmacological ResearchSilvia Diviccaro - University of MilanSilvia Giatti - University of MilanIrwin Goldstein - Pomerado HospitalHeiko Graf - Universität UlmWayne J. G. Hellstrom - Tulane UniversityMichael S. Irwig - Beth Israel Deaconess Medical CenterEmmanuele A. Jannini - University of Rome Tor VergataPaddy K. C. Janssen - Maastricht University Medical CentreMohit Khera - Baylor SchoolManoj Therayil Kumar - MIND InstituteJoanna Le NouryMichal Lew-StarowiczDavid E. J. Linden - Maastricht UniversityCeline Luning - Witten/Herdecke UniversityDee Mangin - McMaster UniversityRoberto Cosimo Melcangi - University of MilanOmar Walid Muquebil Ali Al Shaban Rodriguez - Hospital San AgustinJalesh N. Panicker - National Hospital for Neurology and NeurosurgeryArianna Patacchini - University of FlorenceAmy M. Pearlman - University of IowaCaroline F. Pukall - Queen's UniversitySanjana Raj - Utrecht UniversityYacov Reisman - Hewlett-PackardRachel S. Rubin - Georgetown UniversityRudy Schreiber - Maastricht UniversityStuart Shipko - Private Practice, Pasadena, CA, USA.Barbora Vaseckova - University Hospital BratislavaAhad Waraich
- Resource Type
- Journal article
- Publication Details
- The International journal of risk & safety in medicine, Vol.33(1), pp.65-76
- Publisher
- Ios Press
- DOI
- 10.3233/JRS-210023
- PMID
- 34719438
- PMCID
- PMC8925105
- ISSN
- 0924-6479
- eISSN
- 1878-6847
- Number of pages
- 12
- Grant note
- David Braley Chair in Family Medicine, McMaster University United Kingdom's Department of Health NIHR Biomedical Research Centres 2017S9KTNE_002 / Italian Ministry of University and Research; Ministry of Education, Universities and Research (MIUR)
- Language
- English
- Date published
- 01/01/2022
- Academic Unit
- Urology; Psychological and Quantitative Foundations
- Record Identifier
- 9984320077302771
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