Diaphragmatic Castleman's disease: A rare lymphoproliferative disorder: Clinical and radiological perspectives

Pritish Aher; Raed Zughul; Sameer Samtani; Sarv Priya; Yoel Siegel; Chris Schettino

doi:10.1016/j.radcr.2024.09.077

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Diaphragmatic Castleman's disease: A rare lymphoproliferative disorder: Clinical and radiological perspectives

Journal article

Peer reviewed

Diaphragmatic Castleman's disease: A rare lymphoproliferative disorder: Clinical and radiological perspectives

Pritish Aher, Raed Zughul, Sameer Samtani, Sarv Priya, Yoel Siegel and Chris Schettino

Radiology case reports, Vol.19(12), pp.6390-6393

12/2024

DOI: 10.1016/j.radcr.2024.09.077

PMCID: PMC11461952

PMID: 39387026

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Abstract

Castleman's disease (CD) is a rare, benign nonclonal lymphoproliferative disorder with an unclear etiology, presenting significant diagnostic challenges due to its nonspecific features. CD is categorized into unicentric (UCD) and multicentric (MCD) types, with MCD further divided into HHV-8-associated and idiopathic (iMCD) forms. Clinical manifestations include fever, weight loss, night sweats, and organomegaly, with specific symptoms depending on the subtype. Diagnostic criteria for CD involve a combination of major criteria-histopathologic examination and minor criteria. Imaging techniques, including CT, MRI, and PET-CT, play a crucial role in diagnosis, staging, and differentiation from other diseases. This paper discusses the pathophysiology, clinical features, diagnostic criteria, and imaging findings of CD, illustrated by a case of a patient with renal disease with incidentally detected a right cardiophrenic mass. The case highlights the importance of comprehensive imaging and clinical evaluation in managing CD.

Cardiophrenic mass

Diaphragmatic mass

Lymphoproliferative disorders

Thoracic Castleman disease

Thoracic liposarcoma

Details

Title: Subtitle: Diaphragmatic Castleman's disease: A rare lymphoproliferative disorder: Clinical and radiological perspectives
Creators: Pritish Aher - University of Miami
Raed Zughul - University of Miami
Sameer Samtani - University of Miami
Sarv Priya - Radiology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
Yoel Siegel - University of Miami
Chris Schettino - University of Miami
Resource Type: Journal article
Publication Details: Radiology case reports, Vol.19(12), pp.6390-6393
DOI: 10.1016/j.radcr.2024.09.077
PMID: 39387026
PMCID: PMC11461952
NLM abbreviation: Radiol Case Rep
ISSN: 1930-0433
eISSN: 1930-0433
Publisher: Elsevier Inc
Number of pages: 4
Language: English
Date published: 12/2024
Academic Unit: Radiology
Record Identifier: 9984721238402771

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