Journal article
Diastereoselective Vinyl Addition to Chiral Hydrazones via Tandem Thiyl Radical Addition and Silicon-Tethered Cyclization
Organic letters, Vol.2(26), pp.4237-4240
12/28/2000
DOI: 10.1021/ol0067991
PMID: 11150208
Abstract
A diastereoselective method for addition of a vinyl group to α-hydroxy hydrazones under neutral tin-free radical cyclization conditions, leading to substituted vinylglycinols, is presented. Tandem thiyl radical addition/cyclization upon a silicon-tethered vinyl group followed by treatment with potassium fluoride accomplishes a one-pot neutral vinyl addition process to afford acyclic allylic anti-hydrazino alcohols in good yield.
Details
- Title: Subtitle
- Diastereoselective Vinyl Addition to Chiral Hydrazones via Tandem Thiyl Radical Addition and Silicon-Tethered Cyclization
- Creators
- Gregory K FriestadSara E Massari
- Resource Type
- Journal article
- Publication Details
- Organic letters, Vol.2(26), pp.4237-4240
- Publisher
- American Chemical Society
- DOI
- 10.1021/ol0067991
- PMID
- 11150208
- ISSN
- 1523-7060
- eISSN
- 1523-7052
- Language
- English
- Date published
- 12/28/2000
- Academic Unit
- Chemistry
- Record Identifier
- 9983985955502771
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