Journal article
Dichotomous Role of the Macrophage in Early Mycobacterium marinum Infection of the Zebrafish
Cell host & microbe, Vol.2(1), pp.29-39
07/12/2007
DOI: 10.1016/j.chom.2007.06.004
PMCID: PMC3115716
PMID: 18005715
Abstract
In tuberculosis, infecting mycobacteria are phagocytosed by macrophages, which then migrate into deeper tissue and recruit additional cells to form the granulomas that eventually contain infection. Mycobacteria are exquisitely adapted macrophage pathogens and observations in the mouse model of tuberculosis have suggested that mycobacterial growth is not inhibited in macrophages until adaptive immunity is induced. Using the optically transparent and genetically tractable zebrafish embryo-
Mycobacterium marinum
model of tuberculosis, we have directly examined early infection in the presence and absence of macrophages. The absence of macrophages led rapidly to higher bacterial burdens suggesting that macrophages control infection early and are not an optimal growth niche. However, we show that macrophages play a critical role in tissue dissemination of mycobacteria. We propose that residence within macrophages represents an evolutionary trade-off for pathogenic mycobacteria that slows their early growth but provides a mechanism for tissue dissemination.
Details
- Title: Subtitle
- Dichotomous Role of the Macrophage in Early Mycobacterium marinum Infection of the Zebrafish
- Creators
- Hilary Clay - Molecular and Cellular Biology Graduate Program, University of Washington, Seattle. WA, USAJ. Muse Davis - Immunology and Molecular Pathogenesis Graduate Program, Emory University, Atlanta, GA, USADana Beery - Department of Microbiology, University of Washington. Seattle, WA, USAAnna Huttenlocher - Departments of Pediatrics and Pharmacology, University of Wisconsin. Madison, WI, USASusan Lyons - Department of Internal Medicine, University of Michigan. Ann Arbor, MI, USALalita Ramakrishnan - Department of Microbiology, University of Washington. Seattle, WA, USA
- Resource Type
- Journal article
- Publication Details
- Cell host & microbe, Vol.2(1), pp.29-39
- DOI
- 10.1016/j.chom.2007.06.004
- PMID
- 18005715
- PMCID
- PMC3115716
- ISSN
- 1931-3128
- eISSN
- 1934-6069
- Grant note
- R01 AI054503-09 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID R01 AI036396-19 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID
- Language
- English
- Date published
- 07/12/2007
- Academic Unit
- Stead Family Department of Pediatrics; Infectious Disease (Pediatrics)
- Record Identifier
- 9984093342902771
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