Journal article
Dickinson W. Richards Lecture: Circulatory adjustments to hypoxia
Circulation (New York, N.Y.), Vol.61(3), pp.463-470
03/1980
DOI: 10.1161/01.cir.61.3.463
PMID: 7353235
Abstract
Circulatory adjustments during hypoxia act to redistribute blood flow and maintain arterial pressure. Redistribution of blood flow is accomplished by a local effect of hypoxia, which produces dilatation in coronary and cerebral vessels, and the chemoreceptor reflex, which produces vasoconstriction in skeletal muscle and the splanchnic bed and dilatation in coronary vessels. Arterial pressure is maintained primarily by the chemoreceptor reflex. If the chemoreceptor reflex fails to maintain arterial pressure, hypoxia and hypotension together activate the central pressor response. Compensatory mechanisms usually are sufficient to maintain homeostasis during hypoxia. However, when a hypotensive stress is superimposed during hypoxia, compensatory mechanisms may fail to maintain arterial pressure. Thus, systemic hypoxia interferes with autonomic cardiovascular adjustments.
Details
- Title: Subtitle
- Dickinson W. Richards Lecture: Circulatory adjustments to hypoxia
- Creators
- D D HeistadF M Abboud
- Resource Type
- Journal article
- Publication Details
- Circulation (New York, N.Y.), Vol.61(3), pp.463-470
- DOI
- 10.1161/01.cir.61.3.463
- PMID
- 7353235
- NLM abbreviation
- Circulation
- ISSN
- 0009-7322
- eISSN
- 1524-4539
- Publisher
- Lippincott Williams & Wilkins; United States
- Language
- English
- Date published
- 03/1980
- Academic Unit
- Molecular Physiology and Biophysics; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984025581402771
Metrics
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