Dickkopf-1 Is a Biomarker for Systemic Lupus Erythematosus and Active Lupus Nephritis

Jing Xue; Jiali Yang; Lijuan Yang; Shaolan Zhou; Chen Ji; Xuemei Wang; Nan Yu; Xiaoming Liu; Shuhong Chi

doi:10.1155/2017/6861575

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Dickkopf-1 Is a Biomarker for Systemic Lupus Erythematosus and Active Lupus Nephritis

Journal article

Open access

Peer reviewed

Dickkopf-1 Is a Biomarker for Systemic Lupus Erythematosus and Active Lupus Nephritis

Jing Xue, Jiali Yang, Lijuan Yang, Shaolan Zhou, Chen Ji, Xuemei Wang, Nan Yu, Xiaoming Liu and Shuhong Chi

Journal of immunology research, Vol.2017, 6861575

2017

DOI: 10.1155/2017/6861575

PMCID: PMC5360949

PMID: 28373995

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https://doi.org/10.1155/2017/6861575View

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Abstract

An early diagnosis of lupus nephritis (LN) has an important clinical implication in guiding treatments of systemic lupus erythematosus (SLE) in clinical settings. In this study, the concentrations of Wnt-3A, Frizzled-8 (FZD-8), and Dickkopf-1 (DKK-1) of Wnt signaling, as well as their diagnostic values for accessing LN, were evaluated by ELISA in sera and urine of 111 SLE patients (31 with LN and 80 without LN) and 70 healthy cohorts. Significantly more abundances of DKK-1 protein were determined in both of sera and urine of SLE patients compared to healthy cohorts ( < 0.0001); in particular the serum DKK-1 concentration was even higher in LN-SLE patients relative to non-LN SLE subjects ( < 0.0001). Intriguingly, concentrations of above examined proteins in SLE patients showed no correlation between serum and urine. Moreover, a combination of DKK-1 with anti-dsDNA and/or levels of complement C3 and C4 could not increase the specificity and/or sensitivity for identification of patients with LN diseases, but both ROC curve and multiple-factor nonconditional logistic regression analysis showed that serum DKK-1 was considered better positive biomarker for identification of LN in SLE patients. These results imply that serum and/or urine DKK-1 may be a valuable and independent biomarker for identification of SLE patients with LN.

Severity of Illness Index

Biomarkers - urine

Humans

Middle Aged

Receptors, Cell Surface - analysis

Intercellular Signaling Peptides and Proteins - urine

Wnt3A Protein - blood

Male

Receptors, Cell Surface - blood

Lupus Erythematosus, Systemic - blood

Biomarkers - blood

Intercellular Signaling Peptides and Proteins - blood

Lupus Erythematosus, Systemic - diagnosis

Young Adult

Lupus Erythematosus, Systemic - urine

Wnt3A Protein - urine

Sensitivity and Specificity

Adolescent

Lupus Nephritis - urine

Adult

Female

ROC Curve

Aged

Lupus Nephritis - diagnosis

Details

Title: Subtitle: Dickkopf-1 Is a Biomarker for Systemic Lupus Erythematosus and Active Lupus Nephritis
Creators: Jing Xue - The General Hospital of Ningxia Medical University, Yinchuan 750004, China; College of Life Science, Ningxia University, Yinchuan, Ningxia 750021, China
Jiali Yang - The General Hospital of Ningxia Medical University, Yinchuan 750004, China
Lijuan Yang - Department of Rheumatology, The General Hospital of Ningxia Medical University, Yinchuan 750004, China
Shaolan Zhou - Department of Rheumatology, The General Hospital of Ningxia Medical University, Yinchuan 750004, China
Chen Ji - Department of Rheumatology, The General Hospital of Ningxia Medical University, Yinchuan 750004, China
Xuemei Wang - Department of Rheumatology, The General Hospital of Ningxia Medical University, Yinchuan 750004, China
Nan Yu - Department of Rheumatology, The General Hospital of Ningxia Medical University, Yinchuan 750004, China
Xiaoming Liu - The General Hospital of Ningxia Medical University, Yinchuan 750004, China; College of Life Science, Ningxia University, Yinchuan, Ningxia 750021, China; Institute of Human Stem Cell Research at The General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, China
Shuhong Chi - Department of Rheumatology, The General Hospital of Ningxia Medical University, Yinchuan 750004, China
Resource Type: Journal article
Publication Details: Journal of immunology research, Vol.2017, 6861575
DOI: 10.1155/2017/6861575
PMID: 28373995
PMCID: PMC5360949
NLM abbreviation: J Immunol Res
ISSN: 2314-8861
eISSN: 2314-7156
Publisher: Egypt
Grant note: DOI: 10.13039/501100004772, name: Natural Science Foundation of Ningxia Province, award: NZ1213
Language: English
Date published: 2017
Academic Unit: Anatomy and Cell Biology
Record Identifier: 9984025412702771

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