Diclofenac enables prolonged delivery of naltrexone through microneedle-treated skin

Stan L Banks; Kalpana S Paudel; Nicole K Brogden; Charles D Loftin; Audra L Stinchcomb

doi:10.1007/s11095-011-0372-2

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Diclofenac enables prolonged delivery of naltrexone through microneedle-treated skin

Journal article

Peer reviewed

Diclofenac enables prolonged delivery of naltrexone through microneedle-treated skin

Stan L Banks, Kalpana S Paudel, Nicole K Brogden, Charles D Loftin and Audra L Stinchcomb

Pharmaceutical research, Vol.28(5), pp.1211-1219

05/2011

DOI: 10.1007/s11095-011-0372-2

PMCID: PMC3377386

PMID: 21301935

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Abstract

The purpose of this study was to determine if non-specific COX inhibition could extend pore lifetime in hairless guinea pigs following microneedle treatment. Hairless guinea pigs were treated with microneedle arrays ± daily application of Solaraze® gel (3% diclofenac sodium (non-specific COX inhibitor) and 2.5% hyaluronic acid); transepidermal water loss was utilized to evaluate pore lifetime. To examine the permeation of naltrexone, additional guinea pigs were treated with microneedles ± daily Solaraze® gel followed by application of a 16% transdermal naltrexone patch; pharmacokinetic analysis of plasma naltrexone levels was performed. Histological analysis was employed to visualize morphological changes following microneedle and Solaraze® treatment. Animals treated with microneedles + Solaraze® displayed extended pore lifetime (determined by transepidermal water loss measurements) for up to 7 days. Enhanced naltrexone permeation was also observed for an extended amount of time in animals treated with microneedles + Solaraze®. No morphological changes resulting from microneedle treatment or COX inhibition were noted. Non-specific COX inhibition is an effective means of extending pore lifetime following microneedle treatment in hairless guinea pigs. This may have clinical implications for extending transdermal patch wear time and therefore increasing patient compliance with therapy.

Transdermal Patch

Diclofenac - pharmacology

Narcotic Antagonists - administration & dosage

Guinea Pigs

Skin - metabolism

Cyclooxygenase Inhibitors - pharmacology

Animals

Naltrexone - pharmacokinetics

Skin - ultrastructure

Skin Absorption - drug effects

Cyclooxygenase 1 - metabolism

Narcotic Antagonists - pharmacokinetics

Naltrexone - administration & dosage

Skin - drug effects

Details

Title: Subtitle: Diclofenac enables prolonged delivery of naltrexone through microneedle-treated skin
Creators: Stan L Banks - AllTranz, Inc., Lexington, Kentucky, USA
Kalpana S Paudel
Nicole K Brogden
Charles D Loftin
Audra L Stinchcomb
Resource Type: Journal article
Publication Details: Pharmaceutical research, Vol.28(5), pp.1211-1219
DOI: 10.1007/s11095-011-0372-2
PMID: 21301935
PMCID: PMC3377386
NLM abbreviation: Pharm Res
ISSN: 0724-8741
eISSN: 1573-904X
Publisher: United States
Grant note: R01 DA013425-07 / NIDA NIH HHS R01 DA013425 / NIDA NIH HHS R01DA13425 / NIDA NIH HHS
Language: English
Date published: 05/2011
Academic Unit: Dermatology; Pharmaceutical Sciences and Experimental Therapeutics
Record Identifier: 9984025479302771

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