Journal article
Didemnins: Antiviral and Antitumor Depsipeptides from a Caribbean Tunicate
Science (American Association for the Advancement of Science), Vol.212(4497), pp.933-935
05/22/1981
DOI: 10.1126/science.7233187
PMID: 7233187
Abstract
Extracts of samples of a Caribbean tunicate (ascidian, sea squirt) of the family Didemnidae inhibit in vitro at low concentrations the growth of DNA and RNA viruses as well as L1210 leukemic cells. The active compounds isolated from the tunicate, didemnins A, B, and C, are depsipeptides, and didemnin B (a derivative of didemnin A) is the component active at the lowest concentration in inhibiting viral replication in vitro and P388 leukemia in vivo. Copyright © 1981 AAAS.
Details
- Title: Subtitle
- Didemnins: Antiviral and Antitumor Depsipeptides from a Caribbean Tunicate
- Creators
- Kenneth L Rinehart - Roger Adams Laboratory, University of Illinois, Urbana 61801James B Gloer - Roger Adams Laboratory, University of Illinois, Urbana 61801Robert G Hughes - Department of Cell and Tumor Biology, Roswell Park Memorial Institute, Buffalo, New York 14263Harold E Renis - Upjohn Company, Kalamazoo, Michigan 49001J. Patrick McGovren - Upjohn Company, Kalamazoo, Michigan 49001Everett B Swynenberg - Upjohn Company, Kalamazoo, Michigan 49001Dale A Stringfellow - Upjohn Company, Kalamazoo, Michigan 49001Sandra L Kuentzel - Upjohn Company, Kalamazoo, Michigan 49001Li H Li - Upjohn Company, Kalamazoo, Michigan 49001
- Resource Type
- Journal article
- Publication Details
- Science (American Association for the Advancement of Science), Vol.212(4497), pp.933-935
- DOI
- 10.1126/science.7233187
- PMID
- 7233187
- ISSN
- 0036-8075
- eISSN
- 1095-9203
- Language
- English
- Date published
- 05/22/1981
- Academic Unit
- Chemistry
- Record Identifier
- 9984216568602771
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