Journal article
Diet-Driven Inflammation and Insulinemia and Risk of Interval Breast Cancer
Nutrition and cancer, Vol.74(9), pp.3179-3193
04/06/2022
DOI: 10.1080/01635581.2022.2063350
PMCID: PMC9439260
PMID: 35471124
Abstract
Interval breast cancers (IBCs) emerge after a non-suspicious mammogram and before the patient's next scheduled screen. Risk factors associated with IBC have not been identified. This study evaluated if the empirical dietary inflammatory pattern (EDIP) or empirical dietary index for hyperinsulinemia (EDIH) scores are associated with IBC compared to screen-detected breast cancer. Data were from women 50-79 years-old in the Women's Health Initiative cohort who completed food frequency questionnaires at baseline (1993-98) and were followed through March 31, 2019 for breast cancer detection. Women were identified as having either IBC diagnosed within 1-year after their last negative screening mammogram (N = 317) or screen-detected breast cancer (N = 1,928). Multivariable-adjusted logistic regression analyses were used to estimate odds ratios for risk of IBC compared to screen-detected cancer in dietary index tertiles. No associations were observed between EDIP or EDIH and IBC. Odds ratios comparing the highest to the lowest dietary index tertile were 1.08; 95%CI, 0.78-1.48 for EDIP and 0.92; 95%CI, 0.67-1.27 for EDIH. The null associations persisted when stratified by BMI categories. Findings suggest that diet-driven inflammation or insulinemia may not be substantially associated with IBC risk among postmenopausal women. Future studies are warranted to identify modifiable factors for IBC prevention.
Details
- Title: Subtitle
- Diet-Driven Inflammation and Insulinemia and Risk of Interval Breast Cancer
- Creators
- Zhenzhen Zhang - Oregon Health & Science UniversityFred K. Tabung - The Ohio State UniversityQi Jin - The Ohio State UniversityGrace Curran - Oregon Health & Science UniversityVeronica L. Irvin - Oregon State UniversityJackilen Shannon - Oregon Health & Science UniversityEllen M. Velie - Medical College of WisconsinJoAnn E. Manson - Brigham and Women's HospitalMichael S. Simon - Wayne State UniversityMara Vitolins - Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.Celina I. Valencia - University of ArizonaLinda Snetselaar - College of Public Health, Department of Epidemiology, University of Iowa, Iowa City, Iowa, USA.Sonali Jindal - Oregon Health & Science UniversityPepper Schedin - Oregon Health & Science University
- Resource Type
- Journal article
- Publication Details
- Nutrition and cancer, Vol.74(9), pp.3179-3193
- DOI
- 10.1080/01635581.2022.2063350
- PMID
- 35471124
- PMCID
- PMC9439260
- NLM abbreviation
- Nutr Cancer
- ISSN
- 0163-5581
- eISSN
- 1532-7914
- Publisher
- Taylor & Francis
- Number of pages
- 15
- Grant note
- HHSN268201600018C; HHSN268201600001C; HHSN268201600002C; HHSN268201600003C; HHSN268201600004C / National Heart, Lung, and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) National Institute of Health (NIH) Office of Research on Women's Health K12HD043488 / National Institute of Child Health and Human Development; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) R01CA253302-02S1 / NCI; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) National Cancer Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) Cancer Early Detection Advanced Research (CEDAR) center at Oregon Health & Science University's Knight Cancer Institute
- Language
- English
- Electronic publication date
- 04/06/2022
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984258956602771
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