Diet-Induced Changes in Functional Disability among People with Multiple Sclerosis: A Secondary Pooled Analysis of Two Randomized Controlled Pilot Trials

Allison R. Groux; Elizabeth S. Walker; Farnoosh Shemirani; Jennifer E. Lee; Amanda K. Irish; Linda M. Rubenstein; Linda G. Snetselaar; Warren G. Darling; Terry L. Wahls; Tyler J. Titcomb

doi:10.3390/sclerosis2030011

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Diet-Induced Changes in Functional Disability among People with Multiple Sclerosis: A Secondary Pooled Analysis of Two Randomized Controlled Pilot Trials

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Diet-Induced Changes in Functional Disability among People with Multiple Sclerosis: A Secondary Pooled Analysis of Two Randomized Controlled Pilot Trials

Allison R. Groux, Elizabeth S. Walker, Farnoosh Shemirani, Jennifer E. Lee, Amanda K. Irish, Linda M. Rubenstein, Linda G. Snetselaar, Warren G. Darling, Terry L. Wahls and Tyler J. Titcomb

Sclerosis, Vol.2(3), pp.156-165

07/04/2024

DOI: 10.3390/sclerosis2030011

PMCID: PMC11410177

PMID: 39296470

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https://doi.org/10.3390/sclerosis2030011View

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Abstract

Emerging evidence links dietary interventions to favorable multiple sclerosis (MS) outcomes; however, evidence for the efficacy of dietary interventions on functional disability remains sparse. Data from two 12-week, randomized, controlled pilot trials were pooled to investigate the efficacy of a modified Paleolithic diet (Paleo) on functional disability, as assessed by the MS Functional Composite (MSFC), among people diagnosed with MS. Pooled baseline-referenced MSFC scores were calculated from the nine-hole peg test (NHPT), timed 25-foot walk (T25FW), and Paced Auditory Serial Addition Test (PASAT) Z-scores. There was no significant difference in the mean change in MSFC scores between groups (p = 0.07). In the Paleo group, a significant increase was observed in the MSFC scores (p = 0.03), NHPT (p < 0.001), and PASAT (p = 0.04) Z-scores at 12 weeks, indicating reduced functional disability compared to baseline values. No significant changes were observed within the Control group. Study-specific differences in the MSFC changes between groups were observed. Functional disability was reduced compared to the baseline in the Paleo group, possibly depending on MS type. These results provide preliminary observations on the efficacy of a modified Paleolithic diet for reducing or maintaining functional disability in MS.

Details

Title: Subtitle: Diet-Induced Changes in Functional Disability among People with Multiple Sclerosis: A Secondary Pooled Analysis of Two Randomized Controlled Pilot Trials
Creators: Allison R. Groux - University of Iowa
Elizabeth S. Walker - University of Iowa
Farnoosh Shemirani - University of Iowa
Jennifer E. Lee - University of Iowa
Amanda K. Irish
Linda M. Rubenstein - University of Iowa
Linda G. Snetselaar - University of Iowa
Warren G. Darling - University of Iowa
Terry L. Wahls - University of Iowa
Tyler J. Titcomb - University of Iowa
Resource Type: Journal article
Publication Details: Sclerosis, Vol.2(3), pp.156-165
DOI: 10.3390/sclerosis2030011
PMID: 39296470
PMCID: PMC11410177
NLM abbreviation: Sclerosis
ISSN: 2813-3064
eISSN: 2813-3064
Language: English
Date published: 07/04/2024
Academic Unit: Neurology; Epidemiology; Emergency Medicine; Nursing; Fraternal Order of Eagles Diabetes Research Center; General Internal Medicine; Health, Sport, and Human Physiology ; Internal Medicine
Record Identifier: 9984655341702771

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