Journal article
Diet-induced changes in functional disability are mediated by fatigue in relapsing-remitting multiple sclerosis: A secondary analysis of the WAVES randomized parallel-arm trial
Multiple sclerosis journal - experimental, translational and clinical, Vol.9(4), pp.1-10
10/30/2023
DOI: 10.1177/20552173231209147
PMCID: PMC10617283
PMID: 37916030
Abstract
Background: People with multiple sclerosis (MS) often report dietary modifications; however, evidence on functional outcomes remains sparse.
Objective: Evaluate the impact of the low-saturated fat (Swank) and modified Paleolithic elimination (Wahls) diets on functional disability among people with relapsing-remitting MS.
Methods: Baseline-referenced MS functional composite (MSFC) scores were calculated from nine-hole peg-test (NHPT), timed 25-foot walk, and oral symbol digit modalities test (SDMT-O) collected at four study visits: (a) run-in, (b) baseline, (c) 12 weeks, and (d) 24 weeks. Participants were observed at run-in and then randomized at baseline to either the Swank (n = 44) or Wahls (n = 43) diets.
Results: Among the Swank group, MSFC scores significantly increased from -0.13 ± 0.14 at baseline to 0.10 ± 0.11 at 12 weeks (p = 0.04) and 0.14 ± 0.11 at 24 weeks (p = 0.02). Among the Wahls group, no change in MSFC scores was observed at 12 weeks from 0.10 ± 0.11 at baseline but increased to 0.28 ± 0.13 at 24 weeks (p = 0.002). In both groups, NHPT and SDMT-O z-scores increased at 24 weeks. Changes in MSFC and NHPT were mediated by fatigue.
Discussion: Both diets reduced functional disability as mediated by fatigue.
Details
- Title: Subtitle
- Diet-induced changes in functional disability are mediated by fatigue in relapsing-remitting multiple sclerosis: A secondary analysis of the WAVES randomized parallel-arm trial
- Creators
- Landon J Crippes - University of IowaSolange M Saxby - University of IowaFarnoosh Shemirani - University of IowaBabita Bisht - University of IowaChristine Gill - University of IowaLinda M Rubenstein - University of IowaPatrick Ten Eyck - , Iowa City, IA, USALucas J Carr - University of IowaWarren G Darling - University of IowaKarin F Hoth - University of IowaJohn Kamholz - University of IowaLinda G Snetselaar - University of IowaTyler J Titcomb - University of IowaTerry L Wahls - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Multiple sclerosis journal - experimental, translational and clinical, Vol.9(4), pp.1-10
- DOI
- 10.1177/20552173231209147
- PMID
- 37916030
- PMCID
- PMC10617283
- NLM abbreviation
- Mult Scler J Exp Transl Clin
- eISSN
- 2055-2173
- Publisher
- SAGE Publications
- Grant note
- UL1TR002537 / ; RG-1506- 04312 / ; T32DK112751-06 / ;
- Language
- English
- Date published
- 10/30/2023
- Academic Unit
- Neurology; Psychiatry; Epidemiology; Iowa Neuroscience Institute; Biostatistics; Fraternal Order of Eagles Diabetes Research Center; General Internal Medicine; Holden Comprehensive Cancer Center; Health, Sport, and Human Physiology ; Internal Medicine; Design Biostat and Ethics
- Record Identifier
- 9984501660202771
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