Diet quality and survival after ovarian cancer: results from the Women's Health Initiative

Cynthia A Thomson; Tracy E Crane; Betsy C Wertheim; Marian L Neuhouser; Wenjun Li; Linda G Snetselaar; Karen M Basen-Engquist; Yang Zhou; Melinda L Irwin

doi:10.1093/jnci/dju314

Back

Diet quality and survival after ovarian cancer: results from the Women's Health Initiative

Journal article

Open access

Peer reviewed

Diet quality and survival after ovarian cancer: results from the Women's Health Initiative

Cynthia A Thomson, Tracy E Crane, Betsy C Wertheim, Marian L Neuhouser, Wenjun Li, Linda G Snetselaar, Karen M Basen-Engquist, Yang Zhou and Melinda L Irwin

JNCI : Journal of the National Cancer Institute, Vol.106(11), pp.dju314-dju314

11/2014

DOI: 10.1093/jnci/dju314

PMCID: PMC4271032

PMID: 25335480

Files and links (1)

url

https://doi.org/10.1093/jnci/dju314View

Published (Version of record) Open Access

Abstract

Survival after an ovarian cancer diagnosis is poor. Given the high mortality in these patients, efforts to identify modifiable lifestyle behaviors that could influence survival are needed. Earlier evidence suggests a protective role for vegetables, but no prior studies have evaluated overall dietary quality and ovarian cancer survival. The purpose of this analysis was to evaluate the role of prediagnosis diet quality in ovarian cancer survival. We identified 636 centrally adjudicated cases of ovarian cancer within the Women's Health Initiative Observational Study or Clinical Trials of 161808 postmenopausal women followed from 1995 to 2012. Dietary quality was assessed for the Healthy Eating Index (2005) using a food frequency questionnaire, covariables were obtained from standardized questionnaires, and adiposity was measured by clinic-based measurements of height, weight, and waist circumference. The association between diet quality and mortality was analyzed using Cox proportional hazards regression, adjusted for potential confounders, and stratified by waist circumference, physical activity level, and diabetes status. Tests of statistical significance were two-sided. Overall, higher diet quality was associated with lower all-cause mortality after ovarian cancer (hazard ratio [HR] for highest vs lowest tertile = 0.73; 95% confidence interval [CI] = 0.55 to 0.97, P(trend) = .03). The effect was strongest among women with waist circumference of 88 cm or less and with no history of diabetes (HR = 0.73, 95% CI = 0.54 to 0.98). Physical activity level did not modify the association between diet quality and survival. Our results suggest that overall higher prediagnosis diet quality may protect against mortality after ovarian cancer.

Body Mass Index

Predictive Value of Tests

United States - epidemiology

Women's Health

Humans

Middle Aged

Risk Factors

Ovarian Neoplasms - pathology

Proportional Hazards Models

Feeding Behavior

Ovarian Neoplasms - mortality

Motor Activity

Diabetes Complications - mortality

Waist Circumference

Adiposity

Aged, 80 and over

Female

Surveys and Questionnaires

Aged

Neoplasm Staging

Odds Ratio

Details

Title: Subtitle: Diet quality and survival after ovarian cancer: results from the Women's Health Initiative
Creators: Cynthia A Thomson - University of Arizona
Tracy E Crane - University of Arizona
Betsy C Wertheim - University of Arizona
Marian L Neuhouser - Fred Hutch Cancer Center
Wenjun Li - University of Massachusetts Chan Medical School
Linda G Snetselaar - University of Iowa, Epidemiology
Karen M Basen-Engquist - The University of Texas MD Anderson Cancer Center
Yang Zhou - University of Arizona
Melinda L Irwin - Yale University
Resource Type: Journal article
Publication Details: JNCI : Journal of the National Cancer Institute, Vol.106(11), pp.dju314-dju314
DOI: 10.1093/jnci/dju314
PMID: 25335480
PMCID: PMC4271032
NLM abbreviation: J Natl Cancer Inst
ISSN: 1460-2105
eISSN: 1460-2105
Publisher: Oxford University Press; United States
Language: English
Date published: 11/2014
Academic Unit: Epidemiology; Internal Medicine
Record Identifier: 9983995033402771

Metrics

27 Record Views

74 Times Cited - Web of Science