Dietary Advanced Glycation End-Products and Mortality after Breast Cancer in the Women's Health Initiative

Omonefe O Omofuma; Lindsay L Peterson; David P Turner; Anwar T Merchant; Jiajia Zhang; Cynthia A Thomson; Marian L Neuhouser; Linda G Snetselaar; Bette J Caan; Aladdin H Shadyab; Nazmus Saquib; Hailey R Banack; Jaime Uribarri; Susan E Steck

doi:10.1158/1055-9965.EPI-21-0610

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Dietary Advanced Glycation End-Products and Mortality after Breast Cancer in the Women's Health Initiative

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Dietary Advanced Glycation End-Products and Mortality after Breast Cancer in the Women's Health Initiative

Omonefe O Omofuma, Lindsay L Peterson, David P Turner, Anwar T Merchant, Jiajia Zhang, Cynthia A Thomson, Marian L Neuhouser, Linda G Snetselaar, Bette J Caan, Aladdin H Shadyab, …

Cancer epidemiology, biomarkers & prevention, Vol.30(12), pp.2217-2226

12/2021

DOI: 10.1158/1055-9965.EPI-21-0610

PMCID: PMC8643311

PMID: 34583965

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Abstract

Advanced glycation end-products (AGE) are formed through nonenzymatic glycation of free amino groups in proteins or lipid. They are associated with inflammation and oxidative stress, and their accumulation in the body is implicated in chronic disease morbidity and mortality. We examined the association between postdiagnosis dietary N -carboxymethyl-lysine (CML)-AGE intake and mortality among women diagnosed with breast cancer. Postmenopausal women aged 50 to 79 years were enrolled in the Women's Health Initiative (WHI) between 1993 and 1998 and followed up until death or censoring through March 2018. We included 2,023 women diagnosed with first primary invasive breast cancer during follow-up who completed a food frequency questionnaire (FFQ) after diagnosis. Cox proportional hazards (PH) regression models estimated adjusted hazard ratios (HR) and 95% confidence intervals (CI) of association between tertiles of postdiagnosis CML-AGE intake and mortality risk from all causes, breast cancer, and cardiovascular disease. After a median 15.1 years of follow-up, 630 deaths from all causes were reported (193 were breast cancer-related, and 129 were cardiovascular disease-related). Postdiagnosis CML-AGE intake was associated with all-cause (HR , 1.37; 95% CI, 1.09-1.74), breast cancer (HR , 1.49; 95% CI, 0.98-2.24), and cardiovascular disease (HR , 1.91; 95% CI, 1.09-3.32) mortality. Higher intake of AGEs was associated with higher risk of major causes of mortality among postmenopausal women diagnosed with breast cancer. Our findings suggest that dietary AGEs may contribute to the risk of mortality after breast cancer diagnosis. Further prospective studies examining dietary AGEs in breast cancer outcomes and intervention studies targeting dietary AGE reduction are needed to confirm our findings.

Details

Title: Subtitle: Dietary Advanced Glycation End-Products and Mortality after Breast Cancer in the Women's Health Initiative
Creators: Omonefe O Omofuma - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland
Lindsay L Peterson - Washington University School of Medicine in St. Louis, St. Louis, Missouri
David P Turner - Medical University of South Carolina, Charleston, South Carolina
Anwar T Merchant - Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina
Jiajia Zhang - Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina
Cynthia A Thomson - Mel & Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona
Marian L Neuhouser - Fred Hutchinson Cancer Research Center, Seattle, Washington
Linda G Snetselaar - School of Public Health, University of Iowa, Iowa City, Iowa
Bette J Caan - Kaiser Permanente, University of California Berkeley, Oakland, California
Aladdin H Shadyab - Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, California
Nazmus Saquib - College of Medicine, Sulaiman AlRajhi University, Saudi Arabia
Hailey R Banack - School of Public Health and Health Professions, University at Buffalo-SUNY, Buffalo, New York
Jaime Uribarri - Department of Medicine, Icahn School of Medicine at Mount Sinai, New York
Susan E Steck - Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina. stecks@mailbox.sc.edu
Resource Type: Journal article
Publication Details: Cancer epidemiology, biomarkers & prevention, Vol.30(12), pp.2217-2226
DOI: 10.1158/1055-9965.EPI-21-0610
PMID: 34583965
PMCID: PMC8643311
NLM abbreviation: Cancer Epidemiol Biomarkers Prev
ISSN: 1055-9965
eISSN: 1538-7755
Grant note: HHSN268201100002I / NHLBI NIH HHS U54 CA210962 / NCI NIH HHS HHSN271201100004C / NIA NIH HHS HHSN268201100001C / WHI NIH HHS HHSN268201100004I / NHLBI NIH HHS HHSN268201100004C / WHI NIH HHS HHSN268201100046C / NHLBI NIH HHS HHSN268201100003I / NHLBI NIH HHS R25 CA203650 / NCI NIH HHS HHSN268201100002C / WHI NIH HHS HHSN268201100001I / NHLBI NIH HHS R01 CA245143 / NCI NIH HHS HHSN268201100003C / WHI NIH HHS L30 CA220736 / NCI NIH HHS
Language: English
Date published: 12/2021
Academic Unit: Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
Record Identifier: 9984215143702771

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