Journal article
Dietary Exposure to Brominated Flame Retardants and Abnormal Pap Test Results
Journal of women's health (Larchmont, N.Y. 2002), Vol.20(9), pp.1269-1278
09/01/2011
DOI: 10.1089/jwh.2010.2275
PMCID: PMC3168967
PMID: 21797757
Abstract
Objective: This study examined a possible association of dietary exposure to polybrominated biphenyls (PBBs), a brominated flame retardant, and self-reported abnormal Pap test results and cervical dysplasia as a precursor to cervical cancer.
Methods: Women in Michigan who ingested contaminated poultry, beef, and dairy products in the early 1970s were enrolled in a population-based cohort study in Michigan. Serum PBB and serum polychlorinated biphenyl (PCB) concentrations were measured. Reproductive history and health information, including Pap test results, were self-reported by participants.
Results: Of the women, 23% (223 of 956) reported an abnormal Pap test. In unadjusted analyses, self-reporting an abnormal Pap test was associated with younger age, current smoking (hazard ratio [HR] 1.61, 95% confidence interval [CI] 1.19-2.17), and longer duration of lifetime use of oral contraceptives (>= 10 years; HR 1.92, 95% CI 1.21-3.06). When adjusting for PCB exposure, age at the interview, and smoking history, there was a slightly elevated risk of self-reporting an abnormal Pap test among the highly exposed women compared to women with nondetectable PBB concentrations (PBB >= 13 mu g/L, HR 1.23, 95% CI 0.74-2.06); however, the CI was imprecise. When breastfeeding duration after the initial PBB measurement was taken into account, there was a reduced risk of self-reporting an abnormal Pap test among the highly exposed women who breastfed for >= 12 months (HR 0.41, 95% CI 0.06-3.03; referent group: women with nondetectable PBB concentrations who did not breastfeed).
Conclusions: It remains important to evaluate the potential reproductive health consequences of this class of chemicals as well as other potential predictors of abnormal Pap tests.
Details
- Title: Subtitle
- Dietary Exposure to Brominated Flame Retardants and Abnormal Pap Test Results
- Creators
- Denise J. Jamieson - Emory UniversityMetrecia L. Terrell - Emory UniversityNnenna N. Aguocha - Emory UniversityChanley M. Small - Emory UniversityLorraine L. Cameron - Michigan Dept Community Hlth, Div Environm Hlth, Lansing, MI USAMichele Marcus - Emory University
- Resource Type
- Journal article
- Publication Details
- Journal of women's health (Larchmont, N.Y. 2002), Vol.20(9), pp.1269-1278
- Publisher
- Mary Ann Liebert, Inc
- DOI
- 10.1089/jwh.2010.2275
- PMID
- 21797757
- PMCID
- PMC3168967
- ISSN
- 1540-9996
- eISSN
- 1931-843X
- Number of pages
- 10
- Grant note
- U37/CCU500392 / Centers for Disease Control and Prevention; United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA R01-ES08341; R01-ES012014 / National Institute of Environmental Health Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) R01ES012014 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS)
- Language
- English
- Date published
- 09/01/2011
- Academic Unit
- Obstetrics and Gynecology; VPMA - Administration
- Record Identifier
- 9984446520102771
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