Journal article
Dietary Fat Intake During Adolescence and Breast Density Among Young Women
Cancer epidemiology, biomarkers & prevention, Vol.25(6), pp.918-926
06/2016
DOI: 10.1158/1055-9965.EPI-15-1146
PMCID: PMC4891243
PMID: 27197283
Abstract
Lack of association between fat intake and breast cancer risk in cohort studies might be attributed to the disregard of temporal effects during adolescence when breasts develop and are particularly sensitive to stimuli. We prospectively examined associations between adolescent fat intakes and breast density.
Among 177 women who participated in the Dietary Intervention Study in Children, dietary intakes at ages 10-18 years were assessed on five occasions by 24-hour recalls and averaged. We calculated geometric mean and 95% confidence intervals for MRI-measured breast density at ages 25-29 years across quartiles of fat intake using linear mixed-effect regression.
Comparing women in the extreme quartiles of adolescent fat intakes, percent dense breast volume (%DBV) was positively associated with saturated fat (mean = 16.4% vs. 21.5%; Ptrend < 0.001). Conversely, %DBV was inversely associated with monounsaturated fat (25.0% vs. 15.8%; Ptrend < 0.001) and the ratio of polyunsaturated fat to saturated fat (P/S ratio; 19.1% vs. 14.3%; Ptrend < 0.001). When examining intake by pubertal stages, %DBV was inversely associated with intake of polyunsaturated fat (20.8% vs. 16.4%; Ptrend = 0.04), long-chain omega-3 fat (17.8% vs. 15.8%; Ptrend < 0.001), and P/S ratio (22.5% vs. 16.1%; Ptrend < 0.001) before menarche, but not after. These associations observed with %DBV were consistently observed with absolute dense breast volume but not with absolute nondense breast volume.
In our study, adolescent intakes of higher saturated fat and lower mono- and polyunsaturated fat are associated with higher breast density measured approximately 15 years later.
The fat subtype composition in adolescent diet may be important in early breast cancer prevention. Cancer Epidemiol Biomarkers Prev; 25(6); 918-26. ©2016 AACR.
Details
- Title: Subtitle
- Dietary Fat Intake During Adolescence and Breast Density Among Young Women
- Creators
- Seungyoun Jung - University of Maryland School of Medicine, Baltimore, MarylandOlga Goloubeva - University of Maryland School of Medicine, Baltimore, MarylandCatherine Klifa - Dangeard Group, Luynes, FranceErin S LeBlanc - Kaiser Permanente Center for Health Research, Portland, OregonLinda G Snetselaar - University of Iowa, Iowa City, IowaLinda Van Horn - Feinberg School of Medicine, Northwestern University, Chicago, IllinoisJoanne F Dorgan - University of Maryland School of Medicine, Baltimore, Maryland. jdorgan@som.umaryland.edu
- Resource Type
- Journal article
- Publication Details
- Cancer epidemiology, biomarkers & prevention, Vol.25(6), pp.918-926
- Publisher
- United States
- DOI
- 10.1158/1055-9965.EPI-15-1146
- PMID
- 27197283
- PMCID
- PMC4891243
- ISSN
- 1055-9965
- eISSN
- 1538-7755
- Grant note
- R01 CA104670 / NCI NIH HHS P30 CA086862 / NCI NIH HHS P30 CA060553 / NCI NIH HHS
- Language
- English
- Date published
- 06/2016
- Academic Unit
- Epidemiology; Internal Medicine
- Record Identifier
- 9983995121802771
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