Journal article
Dietary Fat Interacts with PCBs to Induce Changes in Lipid Metabolism in Mice Deficient in Low-Density Lipoprotein Receptor
Environmental health perspectives, Vol.113(1), pp.83-87
01/2005
DOI: 10.1289/ehp.7280
PMCID: PMC1253714
PMID: 15626652
Abstract
There is evidence that dietary fat can modify the cytotoxicity of polychlorinated biphenyls (PCBs) and that coplanar PCBs can induce inflammatory processes critical in the pathology of vascular diseases. To test the hypothesis that the interaction of PCBs with dietary fat is dependent on the type of fat, low-density lipoprotein receptor–deficient (LDL-R
−/−
) mice were fed diets enriched with either olive oil or corn oil for 4 weeks. Half of the animals from each group were injected with PCB-77. Vascular cell adhesion molecule-1 (VCAM-1) expression in aortic arches was non-detectable in the olive-oil–fed mice but was highly expressed in the presence of PCB-77. PCB treatment increased liver neutral lipids and decreased serum fatty acid levels only in mice fed the corn-oil–enriched diet. PCB treatment increased mRNA expression of genes involved in inflammation, apoptosis, and oxidative stress in all mice. Upon PCB treatment, mice in both olive- and corn-oil–diet groups showed induction of genes involved in fatty acid degradation but with up-regulation of different key enzymes. Genes involved in fatty acid synthesis were reduced only upon PCB treatment in corn-oil–fed mice, whereas lipid transport/export genes were altered in olive-oil–fed mice. These data suggest that dietary fat can modify changes in lipid metabolism induced by PCBs in serum and tissues. These findings have implications for understanding the interactions of nutrients with environmental contaminants on the pathology of inflammatory diseases such as atherosclerosis.
Details
- Title: Subtitle
- Dietary Fat Interacts with PCBs to Induce Changes in Lipid Metabolism in Mice Deficient in Low-Density Lipoprotein Receptor
- Creators
- Bernhard Hennig - Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, Iowa, USAGudrun Reiterer - Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, Iowa, USAMichal Toborek - Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, Iowa, USASergey V Matveev - Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, Iowa, USAAlan Daugherty - Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, Iowa, USAEric Smart - Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, Iowa, USALarry W Robertson - Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, Iowa, USA
- Resource Type
- Journal article
- Publication Details
- Environmental health perspectives, Vol.113(1), pp.83-87
- Publisher
- National Institue of Environmental Health Sciences
- DOI
- 10.1289/ehp.7280
- PMID
- 15626652
- PMCID
- PMC1253714
- ISSN
- 0091-6765
- eISSN
- 1552-9924
- Language
- English
- Date published
- 01/2005
- Academic Unit
- Occupational and Environmental Health
- Record Identifier
- 9984002423002771
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