Journal article
Dietary Fructose and Fructose-Induced Pathologies
Annual review of nutrition, Vol.42(1), pp.45-66
08/22/2022
DOI: 10.1146/annurev-nutr-062220-025831
PMID: 35995049
Abstract
The consumption of fructose as sugar and high-fructose corn syrup has markedly increased during the past several decades. This trend coincides with the exponential rise of metabolic diseases, including obesity, nonalcoholic fatty liver disease, cardiovascular disease, and diabetes. While the biochemical pathways of fructose metabolism were elucidated in the early 1990s, organismal-level fructose metabolism and its whole-body pathophysiological impacts have been only recently investigated. In this review, we discuss the history of fructose consumption, biochemical and molecular pathways involved in fructose metabolism in different organs and gut microbiota, the role of fructose in the pathogenesis of metabolic diseases, and the remaining questions to treat such diseases.
Details
- Title: Subtitle
- Dietary Fructose and Fructose-Induced Pathologies
- Creators
- Sunhee Jung - University of California, IrvineHosung Bae - University of California, IrvineWon-Suk Song - Seoul National UniversityCholsoon Jang - University of California, Irvine
- Resource Type
- Journal article
- Publication Details
- Annual review of nutrition, Vol.42(1), pp.45-66
- DOI
- 10.1146/annurev-nutr-062220-025831
- PMID
- 35995049
- ISSN
- 0199-9885
- eISSN
- 1545-4312
- Grant note
- R01 AA029124 / NIAAA NIH HHS
- Language
- English
- Date published
- 08/22/2022
- Academic Unit
- Internal Medicine
- Record Identifier
- 9985217031002771
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