Journal article
Dietary Fructose and Hypertension
Current hypertension reports, Vol.13(1), pp.29-35
02/2011
DOI: 10.1007/s11906-010-0163-x
PMID: 20957458
Abstract
The association between fructose and increased blood pressure is still incompletely defined, because experimental studies have produced dissimilar conclusions. Amplified vasopressor responses to minimal stimuli and differing responses to fructose in peripheral versus central sites may explain the controversy. Fructose induces systemic hypertension through several mechanisms mainly associated with deleterious effects on target organs (kidney, endothelium, heart) exerted by the byproducts of its metabolism, such as uric acid. The kidney is particularly sensitive to the effects of fructose because high loads of this sugar reach renal tissue. In addition, fructose increases reabsorption of salt and water in the small intestine and kidney; thus the combination of salt and fructose has a synergistic effect in the development of hypertension. Clinical and epidemiologic studies have also linked fructose consumption with hypertension. Further studies are warranted in order to understand the role of fructose in the development of hypertension.
Details
- Title: Subtitle
- Dietary Fructose and Hypertension
- Creators
- Magdalena Madero - Department of Nephrology INC Ignacio Chávez Juan Badiano 1 Mexico City 14080 MexicoSantos Perez-Pozo - Renal Unit Son Llatzer Hospital Palm of Majorca (Balearic Islands) 07198 SpainDiana Jalal - Division of Renal Diseases and Hypertension University of Colorado, Denver Mail Stop C281 12700 E 19th Ave. Aurora CO 80045 USARichard Johnson - Division of Renal Diseases and Hypertension University of Colorado, Denver Mail Stop C281 12700 E 19th Ave. Aurora CO 80045 USALaura Sánchez-Lozada - Department of Nephrology INC Ignacio Chávez Juan Badiano 1 Mexico City 14080 Mexico
- Resource Type
- Journal article
- Publication Details
- Current hypertension reports, Vol.13(1), pp.29-35
- Publisher
- Current Science Inc
- DOI
- 10.1007/s11906-010-0163-x
- PMID
- 20957458
- ISSN
- 1522-6417
- eISSN
- 1534-3111
- Language
- English
- Date published
- 02/2011
- Academic Unit
- Nephrology; Internal Medicine
- Record Identifier
- 9984094722302771
Metrics
10 Record Views